IP Library Granted Patent US 8,530,694
Granted Patent B2
US 8,530,694 · App. 13/209,511 · Granted Sep 10, 2013

Proteasome inhibitors

Inventors: Edward J. Olhava (Newton, MA); Mihaela Diana Danca (Mendham, NJ)
Assignee: Millennium Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 8,530,694
App. No.
13/209,511
Granted
Sep 10, 2013
Kind
B2
Abstract

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Claims (6)

1. A compound of formula (I):

or a boronic acid anhydride thereof, wherein:

Z 1 and Z 2 are each hydroxy.

2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

3. A method of treating cancer, comprising treating a patient in need of such treatment with a compound according to claim 1 .

4. A method of treating cancer, comprising treating a patient in need of such treatment with a pharmaceutical composition according to claim 2 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2022
From: MILLENNIUM PHARMACEUTICALS, INC.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 061726/0250 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 16, 2013
From: OLHAVA, EDWARD J.; DANCA, MIHAELA DIANA
To: MILLENNIUM PHARMACEUTICALS INC.
Reel/Frame 030221/0518 →
Continuity (4)
Continuation 12704830 · Feb 12, 2010
Continuation 12217243 · Jul 2, 2008
Continuation 11890412 · Aug 6, 2007
Related Publication 20110301124A1 · Dec 8, 2011