Compositions comprising
View Patent ↗Provided are compositions comprising an extract of Paulownia tomentosa wood and methods of use thereof.
1. A method of reducing skin inflammation in a subject in need thereof comprising applying to skin exhibiting inflammation due to exposure to sun rays, rosacea or acne, a therapeutically effective amount of an extract of Paulownia tomentosa wood, wherein the extract contains paulownin in an amount effective in reducing inflammation.
2. The method of claim 1 , wherein said extract is a polar extract of Paulownia tomentosa wood.
3. The method of claim 2 , wherein said polar extract is extracted using one or more solvents comprising C 1 -C 8 alcohols, C1-C8 glycols, or a combination of two or more thereof.
4. The method of claim 2 , wherein said polar extract is extracted using one or more solvents comprising ethanol, methanol, or combinations thereof.
5. The composition of claim 2 , wherein said extract is extracted using a solvent having a dielectric constant of from about 4 to about 60 at 20° C.
6. The method of claim 1 , wherein said extract is a non-polar extract.
7. The method of claim 1 , wherein said applying step comprises applying from greater than zero to about 20% of the extract of Paulownia tomentosa wood containing paulownin to said skin in need of reducing inflammation.
8. The method of claim 1 , wherein said applying step comprises applying from about 0.01 to about 5% of the extract of Paulownia tomentosa wood containing paulownin to said skin in need of reducing inflammation.
9. The method of claim 1 , wherein said applying step comprises applying a composition comprising an extract of Paulownia tomentosa wood containing paulownin and a carrier to said skin in need of reducing inflammation, and wherein said composition is in the form of a solution, suspension, lotion, cream, serum, gel, stick, spray, ointment, liquid wash, soap bar, shampoo, hair conditioner, paste, foam, powder, mousse, shaving cream, hydrogel, or film-forming product.
10. The method of claim 1 , wherein said composition further comprises an additional anti-inflammatory agent.
11. The method of claim 10 , wherein said additional anti-inflammatory agent comprises a substituted resorcinol or an extract of tanacetum parthenium (Feverfew).
12. The method of claim 1 , wherein said skin in need of reducing skin inflammation is skin exhibiting inflammation due to exposure to sun rays.
13. The method of claim 1 , wherein said skin in need of reducing skin inflammation is skin exhibiting rosacea.
14. The method of claim 1 , wherein said skin in need of reducing skin inflammation is skin exhibiting acne.
15. The method of claim 9 , wherein said composition further comprises butylene glycol.