Hemodialysis system with cassette-based blood and dialyste pumping

1. A hemodialysis system comprising:

a dialyzer;

a dialysate source;

a dialysate pump;

a dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette in fluid communication with the dialyzer;

a blood pump; and

a blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette, the blood cassette including a rigid housing and a flexible membrane attached to the rigid housing, the housing including a from-patient tube connector, a to-patient tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, and wherein the flexible membrane defines a valve seat for opening and closing a to-patient line of the blood cassette, the to-patient line in fluid communication with the to-patient tube connector.

2. The hemodialysis system of claim 1 , which includes an internal air separation chamber connected fluidly to the from-dialyzer tube connector and the to-patient tube connector.

3. The hemodialysis system of claim 1 , which further includes a tube connector for priming the blood cassette.

4. The hemodialysis system of claim 1 , wherein the blood cassette is operably connected to the blood pump via a blood pumping tube extending outside of the rigid housing, the blood pumping tube connected fluidly to the from-patient tube connector and the to-dialyzer tube connector.

5. The hemodialysis system of claim 1 , wherein at least one of the tube connectors is a tube port.

6. The hemodialysis system of claim 1 , wherein the to-dialyzer tube connector is in operation located elevationally above the to-patient tube connector.

7. The hemodialysis system of claim 1 , wherein the to-dialyzer tube connector is in operation located elevationally above the from-patient tube connector.

8. The hemodialysis system of claim 1 , wherein the to-dialyzer tube connector is in operation located elevationally at the top of the blood cassette.

9. The hemodialysis system of claim 1 , wherein at least one of the from-patient tube connector, to-patient tube connector, to-dialyzer tube connector, and from-dialyzer tube connector extends outwardly from an outer wall of the housing to accept the respective tube.

10. The hemodialysis system of claim 1 , wherein the blood cassette further includes a blood pumping tube for operable connection to the blood pump.

11. The hemodialysis system of claim 10 , wherein the blood pumping tube is a linear peristaltic blood pumping tube.

12. The hemodialysis system of claim 1 , which includes at least one pressure sensor, and wherein the blood cassette further includes at least one pressure sensing area positioned and arranged for operable engagement with the at least one pressure sensor.

13. The hemodialysis system of claim 12 , which includes arterial and venous pressure sensors and mating arterial and venous pressure sensing areas on the blood cassette.

14. The hemodialysis system of claim 1 , wherein lines internal to the housing of the blood cassette are valved.

15. The hemodialysis system of claim 1 , wherein the blood cassette and the dialysate cassette are integrated into a single cassette.

16. A hemodialysis system comprising:

a dialyzer;

a blood pump;

fresh and used dialysate pumps;

a blood cassette including a rigid housing and a flexible membrane attached to the rigid housing, the rigid housing including a blood pumping tube operatively connected to the blood pump for pumping blood through the blood cassette, the housing further including a from-patient tube connector, a to-patient tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, a valve seat defined by the flexible membrane for opening and closing a to-patient line of the blood cassette, the to-patient line in fluid communication with the to-patient tube connector, a fresh dialysate pumping tube operatively connectable to the fresh dialysate pump, and a used dialysate pumping tube operatively connectable to the used dialysate pump;

wherein the fresh and used dialysate pumps are operable with a dialysate cassette separate from the blood cassette, the dialysate cassette in fluid communication with the dialyzer; and

wherein at least one of the tube connectors is a tube port.

17. The hemodialysis system of claim 16 , wherein the blood pumping tube, the fresh dialysate pumping tube and the used dialysate pumping tube are each linear peristaltic pumping tubes.

18. A hemodialysis system comprising:

a dialyzer;

a blood pump;

fresh and used dialysate pumps;

a cassette including a rigid housing and a flexible membrane attached to the rigid housing, the rigid housing including a blood pumping tube operatively connected to the blood pump for pumping blood through the cassette, the housing further including a from-patient tube connector, a to-patient tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, a valve seat defined by the flexible membrane for opening and closing a to-patient line of the cassette, the to-patient line in fluid communication with the to-patient tube connector, a fresh dialysate pumping tube operatively connectable to the fresh dialysate pump, and a used dialysate pumping tube operatively connectable to the used dialysate pump; and

wherein the cassette further includes a vent to vent air removed from blood within the cassette.

19. A hemodialysis system comprising:

a dialyzer;

a blood pump;

fresh and used dialysate pumps;

a cassette including a rigid housing and a flexible membrane attached to the rigid housing, the rigid housing including a blood pumping tube operatively connected to the blood pump for pumping blood through the cassette, the housing further including a from-patient tube connector, a to-patient tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, a valve seat defined by the flexible membrane for opening and closing a to-patient line of the cassette, the to-patient line in fluid communication with the to-patient tube connector, a fresh dialysate pumping tube operatively connectable to the fresh dialysate pump, and a used dialysate pumping tube operatively connectable to the used dialysate pump; and

wherein the cassette includes an air separation chamber formed within the housing.

20. A hemodialysis system comprising:

a dialyzer;

a blood pump; and

a blood cassette including a housing and a pumping tube, the pumping tube located outside of the housing and extending along a first side of the housing, the pumping tube operatively connected to the blood pump such that the blood pump in operation contacts the pumping tube for pumping blood through the cassette, the housing including a from-patient tube connector, a to-patient tube connector, a saline/priming tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, and wherein each of the connectors extends along a side of the housing different from the first side of the housing.

21. The hemodialysis system of claim 20 , wherein each of the tube connectors extends along a side of the housing opposing the first side of the housing.

22. The hemodialysis system of claim 20 , wherein at least one of the tube connectors is a tube port.

23. The hemodialysis system of claim 20 , wherein each of the connectors is integral with and extends from the housing.