Method for enhancing immune response with peptide
View Patent ↗An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
1. An immunogenic peptide that induces an enhanced immune response consisting of amino acids selected from the group consisting of the 1st-29th, 1st-30th, 1st-31st, 1st-35th, 1st-36th, 1st-37th, 1st-38th, 1st-39th, 1st-41st and 1st-42nd of an amyloid β peptide with the insertion of cysteine-between the 18th and 19th amino acid residues, between the 25th and 26th amino acid residues, or between the 28th and 29th amino acid residues counted from the N-terminus of the amyloid β peptide.
2. The immunogenic peptide according to claim 1 , wherein cysteine is inserted into the amyloid β peptide between the 18th and 19th amino acid residues counted from the N-terminus of the amyloid β peptide.
3. The immunogenic peptide according to claim 1 , wherein cysteine is inserted into the amyloid β peptide between the 25th and 26th amino acid residues counted from the N-terminus of the amyloid β peptide.
4. The immunogenic peptide according to claim 1 , wherein cysteine is inserted into the amyloid β peptide between the 28th and 29th amino acid residues counted from the N-terminus of the amyloid β peptide.
5. The immunogenic peptide according to claim 1 , wherein the amyloid β peptide consists of the amino acid sequence of SEQ ID NO: 34.
6. A medicament comprising the immunogenic peptide according to claim 1 as an active ingredient, and a pharmaceutically acceptable excipient.
7. A medicament comprising the immunogenic peptide according to claim 1 as an active ingredient, a pharmaceutically acceptable excipient, and an adjuvant.
8. A medicament comprising the immunogenic peptide according to claim 1 as an active ingredient, and a pharmaceutically acceptable excipient, with the proviso that the medicament does not comprise an adjuvant.