Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives
View Patent ↗Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles can comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.
1. An article comprising:
a conformable backing member comprising a sheet; and
a pressure-sensitive adhesive (PSA) comprising a poly(D,L-lactide-co-glycolide-co-ε-caprolactone) having a molecular weight (M w ) of from 60,000 to 130,000 Daltons and a polydispersity index (PDI) of less than 2.0; wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) exhibits storage modulus (G′) values of from about 1.5×10 5 Pa to about 5.5×10 5 Pa, over a frequency of from about 0.1 to about 1 Hz; and exhibits storage modulus (G′) values of from about 1.0×10 6 Pa to about 4.0×10 6 Pa, over a frequency of from about 10 2 to about 10 4 Hz at 30° C., and having a surface thereof coated to the conformable backing member;
wherein the PSA coats 0.1% to 100% of the surface area of the conformable backing member.
2. The article of claim 1 , wherein the PSA further comprises a bioactive agent.
3. The article of claim 1 , wherein the conformable backing member further comprises a bioactive layer.
4. The article of claim 1 , wherein the PSA comprises an enzyme inhibitor to increase wound healing.
5. The article of claim 1 , wherein the conformable backing member comprises gauze.
6. The article of claim 1 , wherein the PSA is impregnated with chlorhexidine gluconate.
7. The article of claim 1 , wherein the article is an anti-microbial carrier.
8. The article of claim 1 , wherein the article is wrapped around an internal tissue or bone.
9. The article of claim 1 , wherein the article is formed into a sealable package.
10. The article of claim 9 , wherein the article formed is an envelope.
11. The article of claim 9 , wherein the article formed contains a gel or liquid comprising a bioactive agent.
12. The article of claim 1 , wherein the article is a diaper and the edges or seams of the diaper are adhered with the PSA.
13. The article of claim 1 , wherein the article is compostable packing and the edges or seams of the compostable packing are adhered with the PSA.
14. The article of claim 1 , wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) comprises from 10 to 60 mol % D,L-lactide, from 10 to 50 mol % D,L-glycolide, and from 10 to 80 mol % ε-caprolactone.
15. The article of claim 1 , wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) comprises from 20 to 40 mol % D,L-lactide, from 10 to 30 mol % D,L-glycolide, and from 40 to 60 mol % ε-caprolactone.
16. The article of claim 1 , wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) comprises 30 mol % D,L-lactide, 20 mol % D,L-glycolide, and 50 mol % ε-caprolactone.
17. The article of claim 1 , wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) has a polydispersity index (PDI) ranging from 1.5 to 1.8.
18. The article of claim 1 , wherein the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) has a molecular weight (M w ) of from 100,000 to 130,000 Daltons.
19. An article, comprising:
a conformable backing member comprising a sheet; and
a pressure-sensitive adhesive (PSA) comprising a blend comprising:
(a) a first poly(D,L-lactide-co-glycolide-co-ε-caprolactone) having a molecular weight (M w ) of from 75,000 to 250,000 Daltons and a polydispersity index (PDI) of less than 2.0, and
(b) a second poly(D,L-lactide-co-glycolide-co-ε-caprolactone) having a molecular weight (M w ) of 130,000 Daltons or less and a polydispersity index (PDI) of less than 2.0;
wherein the second poly(D,L-lactide-co-glycolide-co-ε-caprolactone) has a molecular weight (M w ) that is less than the first poly(D,L-lactide-co-glycolide-co-ε-caprolactone); and
wherein the weight ratio of the first poly(D,L-lactide-co-glycolide-co-ε-caprolactone) to the second poly(D,L-lactide-co-glycolide-co-ε-caprolactone) is from about 90:10 to about 60:40,
and having a surface of the PSA coated to the conformable backing member;
wherein the PSA coats 0.1% to 100% of the surface area of the conformable backing member.
20. An article, comprising:
a conformable backing member comprising a sheet; and
a pressure-sensitive adhesive (PSA) comprising a blend comprising
(a) a poly(D,L-lactide-co-glycolide-co-ε-caprolactone) having a molecular weight of from 75,000 to 250,000 Daltons and a polydispersity index (PDI) of less than 2.0, and
(b) a poly(D,L-lactide-co-glycolide-co-mPEG) having a molecular weight of less than 25,000 Daltons and a polydispersity index (PDI) of less than 2.0; and
wherein the weight ratio of the poly(D,L-lactide-co-glycolide-co-ε-caprolactone) to the poly(D,L-lactide-co-glycolide-co-mPEG) is from about 95:5 to about 75:25,
and having a surface of the PSA coated to the conformable backing member;
wherein the PSA coats 0.1% to 100% of the surface area of the conformable backing member.