Crystalline forms of a factor Xa inhibitor
View Patent ↗Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.
1. A crystalline form of betrixaban maleate, which is Form II, having an X-ray powder diffraction pattern having at least the following characteristic peak locations of 10.1, 14.6, 18.0, and 22.0 degrees 2θ (each ±0.1 degrees 2θ).
2. The crystalline form of claim 1 , wherein the X-ray powder diffraction pattern has at least eight characteristic peak locations selected from 10.1, 14.6, 18.0, 19.6, 22.0, 23, 23.7, 24.5, 29.2, 29.5, 30.4, and 35.0 degrees 2θ (each ±0.1 degrees 2θ).
3. The crystalline form of claim 1 , having an X-ray powder diffraction pattern approximate to the X-ray powder diffraction pattern shown in FIG. 2 or 3 .
4. The crystalline form of claim 1 , having a melting point of about 213° C.
5. The crystalline form of claim 1 , having a unit cell containing two independent salt pairs of betrixaban and maleic acid wherein the imine N of betrixaban is protonated and forms an ionic H-bond to the maleic acid counter-ion.
6. The crystalline form of claim 1 , characterized by a unit cell structure with the following cell parameters at 100 K: a=8.284 A, b=18.082 A, c=18.681 A, α=71.22°, β=86.76°, γ=89.69°, and V=2645 A 3 .
7. The crystalline form of claim 1 , characterized by a unit cell structure with the following cell parameters at 273 K: a=8.419 A, b=18.113 A, c=18.73 A, α=71.14°, β=86.71°, γ=89.31°, and V=2699 A 3 .
8. A composition comprising a pharmaceutically acceptable carrier and the crystalline form of claim 1 .