IP Library › Granted Patent US 8,318,147
Granted Patent B2
US 8,318,147 · App. 13/225,741 · Granted Nov 27, 2012

Use of IL-29 for treating a dengue virus infection

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Quick Facts
Patent No.
US 8,318,147
App. No.
13/225,741
Granted
Nov 27, 2012
Kind
B2
Abstract

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Claims (4)

1. A method of treating a Dengue virus infection in a mammal comprising administering to the mammal a therapeutically effective amount of a polypeptide comprising an amino acid sequence having at least 95% sequence identity to-amino acid residues 20-200 of SEQ ID NO:34, and wherein after administration of the polypeptide the Dengue virus infection is reduced.

2. The method of claim 1 wherein the polypeptide is conjugated to a polyalkyl oxide moiety.

3. The method of claim 2 wherein the polyalkyl oxide moiety is a polyethylene glycol.

4. The method of claim 1 , wherein the polypeptide comprises amino acid 20-200 of SEQ ID NO:34.