Self-lubricating pharmaceutical syringe stoppers
View Patent ↗In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.
1. A self-lubricating component for a pharmaceutical packaging assembly comprising a polymer composition comprising an effective amount of lubricating additive, wherein the lubricating additive comprises hexagonal boron nitride and wherein the component is in the form of a plunger, piston, diaphragm, or valve disc for medical equipment.
2. The component of claim 1 where the lubricating additive further comprises zinc stearate, oleamide, erucamide, pentaerythitol stearate or any salt, ester or amide of a fatty acid.
3. The component of claim 1 , wherein the lubricating additive is present in an amount of from about 0.1 to about 50% by weight of the polymer composition.
4. The component of claim 1 , wherein the lubricating additive is present in an amount of from about 3 to about 20% by weight of the polymer composition.
5. The component of claim 1 , wherein the lubricating additive is present in an amount of from about 5 to about 10% by weight of the polymer composition.
6. A pharmaceutical package assembly comprising a barrel having an interior surface coated with a lubricating polymeric composition comprising a lubricating additive, wherein the lubricating additive comprises hexagonal boron nitride.
7. The pharmaceutical package assembly of claim 6 , wherein the lubricating additive is present in an amount of from about 3 to about 20% by weight of the polymer composition.
8. The pharmaceutical package assembly of claim 6 , wherein the lubricating additive is present in an amount of from about 5 to about 10% by weight of the polymer composition.
9. The pharmaceutical package assembly of claim 6 further comprising a plunger.
10. The pharmaceutical package assembly of claim 9 , wherein the plunger is a self-lubricating component comprising a polymer composition comprising an effective amount of lubricating additive.
11. The pharmaceutical package assembly of claim 10 , where the lubricating additive comprises one or more of: boron nitride, graphite, molybdenum disulfide, talc, mica, colloidal silica, fumed silica, high molecular weight silicone gum, Reimer's salt, siloxane particles, vinylfluoro silicones, D4, a salt, ester, or amide of a fatty acid, or any combination of two or more thereof.
12. The pharmaceutical package assembly of claim 9 , wherein at least a portion of a surface of the plunger is coated with a lubricating polymeric composition comprising a lubricating additive.
13. A pharmaceutical package assembly comprising a plunger having at least part of its surface coated with a lubricating polymeric composition comprising a lubricating additive, where the lubricating additive comprises hexagonal boron nitride.
14. The package assembly of claim 13 , wherein the lubricating additive is present in an amount of from about 0.1 to about 50% by weight of the polymer composition.
15. The package assembly of claim 13 , wherein the lubricating additive is present in an amount of from about 3 to about 20% by weight of the polymer composition.
16. The package assembly of claim 13 , wherein the lubricating additive is present in an amount of from about 5 to about 10% by weight of the polymer composition.
17. The component of claim 1 , wherein the lubricating additive further comprises one or more of: boron nitride, graphite, molybdenum disulfide, talc, mica, colloidal silica, fumed silica, high molecular weight silicone gum, Reimer's salt, siloxane particles, a salt, ester, or amide of a fatty acid, vinylfluoro silicones, D4 or any combination of two or more thereof.
18. The pharmaceutical package assembly of claim 6 , wherein the lubricating additive is chosen from one or more of: boron nitride, graphite, molybdenum disulfide, talc, mica, colloidal silica, fumed silica, high molecular weight silicone gum, Reimer's salt, siloxane particles, a salt, ester, or amide of a fatty acid, vinylfluoro silicones, D4 or any combination of two or more thereof.
19. The pharmaceutical package assembly of claim 13 , wherein the lubricating additive is chosen from one or more of: boron nitride, graphite, molybdenum disulfide, talc, mica, colloidal silica, fumed silica, high molecular weight silicone gum, Reimer's salt, siloxane particles, a salt, ester, or amide of a fatty acid, vinylfluoro silicones, D4 or any combination of two or more thereof.