6-aminoisoquinoline compounds
View Patent ↗6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
1. A compound according to Formula (I):
wherein A is —NH—C*H 2 , —NR 10 —C*H 2 —, —CH 2 —O*—, wherein * indicates the atom directly attached to the carbonyl portion of Formula (I), and wherein R 10 is hydrogen, unsubstituted C 1 -C 4 alkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkynyl, or amino;
wherein R 1 , and R 2 are, independently, hydrogen, hydroxyl, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, amino, nitro, cyano, C 1 -C 4 carbonyl, C 1 -C 4 carbonylamino, C 1 -C 4 alkoxy, C 1 -C 4 sulfonyl, C 1 -C 4 sulfonylamino, C 1 -C 4 thioalkyl or C 1 -C 4 carboxyl; and
wherein R 3 is halogen, alkenyl, alkynyl, alkoxy, amino, cyano, cycloalkyl, heterocycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonyl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl.
2. A pharmaceutical composition comprising the compound according to claim 1 .
3. A method of treating a condition comprising administering to a subject in need of treatment a safe and effective amount of a compound of claim 1 , wherein the condition is eye disease.