Intermediates useful in the preparation of maleimide functionalized polymers
View Patent ↗Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
1. A compound of the following structure:
wherein:
X is selected from the group consisting of alkylene, substituted alkylene, alkenylene, substituted alkenylene, —C(O)—, heteroatom and substituted heteroatom;
each of R 1 , R 2 , R 3 and R 4 is independently selected from the group consisting of H, halo, hydroxyl, carboxyl, carboxylalkyl, thiol, alkylthio, acyl, acyloxy, nitro, cyano, azido, trihalomethyl, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkoxy, aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, and substituted heteroaryl; and
n′ is 2 to about 10.
2. The compound of claim 1 , wherein X is a heteroatom.
3. The compound of claim 2 , wherein the heteroatom is O.
4. The compound of claim 1 , wherein each of R 1 , R 2 , R 3 and R 4 is H.
5. The compound of claim 1 , wherein n′ is 2.
6. The compound of claim 1 , wherein X is O, each of R 1 , R 2 , R 3 and R 4 is H, and n′ is 2.