THERAPEUTIC AGENT FOR INTRANASAL ADMINISTRATION AND METHOD OF MAKING AND USING SAME
The present invention provides a composition suitable for intranasal administration comprising capsaicin, dihydrocapsaicin, and nordihydrocapsaicin in the form of capsicum used as a therapeutic agent.
1 . A composition comprising:
an aqueous homeopathic dilution of capsicum;
wherein the composition is suitable for intranasal administration to a human in need thereof;
wherein fast relief is defined as first relief from at least one rhinitis symptom occurring within about 30 minutes of administration.
2 . The composition of claim 1 , wherein the homeopathic dilution of capsicum is at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids.
3 . The composition of claim 1 , wherein the homeopathic dilution of capsicum is at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
4 . The composition of claim 1 , wherein the homeopathic dilution of capsicum is at a concentration of about 0.0030% to about 0.0080% w/w containing about 0.5 to about 1.5 ppm total capsaicinoids.
5 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.02% to about 0.25% w/w.
6 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.05% to about 0.08% w/w.
7 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
8 . The composition of claim 1 , wherein the first relief from symptoms occurs within about 15 minutes of administration.
9 . The composition of claim 1 , wherein the first relief from symptoms occurs within about 5 minutes of administration.
10 . The composition of claim 1 , wherein the first relief from symptoms occurs within about 3 minutes of administration.
11 . The composition of claim 1 , wherein the first relief from symptoms occurs within about 1 minute of administration.
12 . The composition of claim 1 , wherein the at least one rhinitis symptom relieved comprise nasal congestion, sinus pressure, headache, sinus pain or a combination thereof.
13 . The composition of claim 9 , wherein the at least one rhinitis symptom relieved comprise one or more of nasal congestion, sinus pressure, headache or a combination thereof.
14 . The composition of claim 1 , comprising eucalyptol at a concentration of about 0.07% to about 0.15% w/w.
15 . The composition of claim 1 , comprising vegetable glycerin at a concentration of about 3.5% to about 5.0% w/w.
16 . The composition of claim 1 , comprising vegetable glycerin at a concentration of about 3.9% to about 4.5% w/w.
17 . The composition of claim 1 , comprising ascorbic acid at a concentration of about 0.10% to about 0.90% w/w.
18 . The composition of claim 1 , comprising sea salt at a concentration of about 0.40% to about 1.2% w/w.
19 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
wherein the composition is suitable for intranasal administration to a human in need thereof;
wherein the first relief from at least one rhinitis symptom occurs within about 30 minutes of administration.
20 . The composition of claim 19 , wherein the aqueous solution of capsicum is at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
21 . The composition of claim 19 , wherein the aqueous solution of capsicum is at a concentration of about 0.0030% to about 0.0080% w/w containing about 0.5 to about 1.5 ppm total capsaicinoids.
22 . The composition of claim 19 , comprising rosemary extract at a concentration of about 0.02% to about 0.25% w/w.
23 . The composition of claim 19 , comprising rosemary extract at a concentration of about 0.05% to about 0.1% w/w.
24 . The composition of claim 19 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
25 . The composition of claim 19 , wherein the first relief from at least one symptom occurs within about 15 minutes of administration.
26 . The composition of claim 19 , wherein the first relief from at least one symptoms occur within about 5 minutes of administration.
27 . The composition of claim 19 , wherein the first relief from at least one symptom occurs within about 3 minutes of administration.
28 . The composition of claim 19 , wherein the first relief from at least one symptom occurs within about 1 minute of administration.
29 . The composition of claim 19 , wherein the at least one rhinitis symptom relieved comprises nasal congestion, sinus pressure, headache, sinus pain or a combination thereof.
30 . The composition of claim 26 , wherein the at least one rhinitis symptom relieved comprises nasal congestion, sinus pressure, headache or a combination thereof.
31 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
wherein the composition is suitable for intranasal administration to a human in need thereof;
wherein the first relief from at lease one rhinitis symptom occurs within about 30 minutes of administration.
32 . The composition of claim 31 , wherein the aqueous solution of capsicum is at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
33 . The composition of claim 31 , wherein the aqueous solution of capsicum is at a concentration of about 0.0030% to about 0.0080% w/w containing about 0.5 to about 1.5 ppm total capsaicinoids.
34 . The composition of claim 31 , comprising rosemary extract at a concentration of about 0.05% to about 0.1% w/w.
35 . The composition of claim 31 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
36 . The composition of claim 31 , wherein the first relief from symptoms occurs within about 15 minutes of administration.
37 . The composition of claim 31 , wherein the first relief from symptoms occurs within about 5 minutes of administration.
38 . The composition of claim 31 , wherein the first relief from symptoms occurs within about 3 minutes of administration.
39 . The composition of claim 31 , wherein the first relief from symptoms occurs within about 1 minute of administration.
40 . The composition of claim 31 , wherein the rhinitis symptoms relieved comprise at least one of nasal congestion, sinus pressure, headache, sinus pain or a combination thereof.
41 . The composition of claim 37 , wherein the at least one rhinitis symptom relieved comprises nasal congestion, sinus pressure, headache or a combination thereof.
42 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
wherein the composition is suitable for intranasal administration in a human in need thereof;
wherein the first relief from at least one symptom occurs within about 5 minutes of administration; and
wherein the symptoms comprise at least one of nasal congestion, sinus pressure, headache or a combination thereof.
43 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
eucalyptol at a concentration of about 0.07% to about 0.15% w/w;
vegetable glycerin at a concentration of about 3.5% to about 5.0% w/w;
wherein the composition is suitable for intranasal administration in a human in need thereof;
wherein the first relief from at least one symptom occurs within about 5 minutes of administration; and
wherein symptoms consist of at least one of nasal congestion, sinus pressure, headache or a combination thereof.
44 . The composition of claim 43 , comprising ascorbic acid at a concentration of about 0.10% to about 0.90% w/w and sea salt at a concentration of about 0.40% to about 1.2% w/w.
45 . The composition of claim 43 , wherein the first relief from at least one symptom occurs within about 3 minutes of administration.
46 . The composition of claim 43 , wherein the first relief from at least one symptom occurs within about 1 minute of administration.
47 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
wherein the composition is suitable for intranasal administration to a human in need thereof;
wherein the composition does not require the administration of a second agent to enable tolerance of the composition;
wherein the first relief from at least one rhinitis symptom occurs within about 30 minutes of administration.
48 . A composition comprising:
an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
wherein the composition is suitable for intranasal administration to a human in need thereof;
wherein the composition is self-administered;
wherein the first relief from at least one rhinitis symptom occurs within about 30 minutes of administration.
49 . A method for intranasal administration of an aqueous homeopathic dilution of capsicum to a human in need thereof comprising the steps of:
administering intranasally a solution comprising about 0.00060% to about 0.010% w/w capsicum containing about 0.1 to about 2.0 ppm total capsaicinoids and rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
effecting the first relief from at least one symptom nasal congestion, sinus pressure, sinus pain, headache or a combination thereof within about 30 minutes of administration.
50 . The method of claim 47 wherein the capsicum is present in solution at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
51 . The method of claim 47 , wherein the first relief from at least one symptom occurs within about 5 minutes of administration.