THERAPEUTIC AGENT FOR INTRANASAL ADMINISTRATION AND METHOD OF MAKING AND USING SAME
The present invention provides a composition suitable for intranasal administration comprising capsaicin, dihydrocapsaicin, and nordihydrocapsaicin in the form of capsicum used as a therapeutic agent.
1 . A composition suitable for intranasal administration to a human in need thereof comprising:
an effective amount of an aqueous homeopathic dilution of capsicum;
wherein the composition is suitable for intranasal administration;
wherein administration of the composition relieves at least one rhinitis symptom in the human in need thereof.
2 . The composition of claim 1 , wherein the rhinitis is vasomotor rhinitis.
3 . The composition of claim 1 , wherein the rhinitis is non-allergic rhinitis.
4 . The composition of claim 1 , wherein the rhinitis is allergic rhinitis.
5 . The composition of claim 1 , wherein the rhinitis is mixed rhinitis.
6 . The composition of claim 1 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
7 . The composition of claim 1 , wherein the rhinitis is idiopathic rhinitis.
8 . The composition of claim 1 , wherein the rhinitis symptom relieved comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
9 . The composition of claim 1 , wherein the rhinitis symptom relieved comprises nasal congestion.
10 . The composition of claim 1 , wherein the rhinitis symptom relieved comprises sinus pressure.
11 . The composition of claim 1 , wherein the rhinitis symptom relieved comprises sinus pain.
12 . The composition of claim 1 , wherein the rhinitis symptom relieved comprises headache.
13 . The composition of claim 1 wherein the composition does not require the administration of a second agent to enable tolerance of the composition.
14 . The composition of claim 1 wherein the composition is self-administered.
15 . The composition of claim 1 , wherein the homeopathic dilution of capsicum comprises about 0.1 to about 2.0 ppm total capsaicinoids.
16 . The composition of claim 1 , wherein the homeopathic dilution of capsicum comprises about 0.3 to about 1.5 ppm total capsaicinoids.
17 . The composition of claim 1 , wherein the homeopathic dilution of capsicum comprises about 0.5 to about 1.5 ppm total capsaicinoids.
18 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.02% to about 0.25% w/w.
19 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.05% to about 0.10% w/w.
20 . The composition of claim 1 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
21 . The composition of claim 1 , comprising eucalyptol at a concentration of about 0.07% to about 0.15% w/w.
22 . The composition of claim 1 , comprising vegetable glycerin at a concentration of about 3.5% to about 5.0% w/w.
23 . The composition of claim 1 , comprising vegetable glycerin at a concentration of about 3.9% to about 4.5% w/w.
24 . The composition of claim 1 , comprising ascorbic acid at a concentration of about 0.10% to about 0.90% w/w.
25 . The composition of claim 1 , comprising sea salt at a concentration of about 0.40% to about 1.2% w/w.
26 . A composition suitable for intranasal administration to a human in need thereof comprising:
an effective amount of an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
wherein the composition is suitable for intranasal administration;
wherein administration of the composition relieves at least one rhinitis symptom in the human in need thereof.
27 . The composition of claim 26 , wherein the rhinitis is vasomotor rhinitis.
28 . The composition of claim 26 , wherein the rhinitis is non-allergic rhinitis.
29 . The composition of claim 26 , wherein the rhinitis is allergic rhinitis.
30 . The composition of claim 26 , wherein the rhinitis is mixed rhinitis.
31 . The composition of claim 26 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
32 . The composition of claim 26 , wherein the rhinitis is idiopathic rhinitis.
33 . The composition of claim 26 , wherein the rhinitis symptom relieved comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
34 . The composition of claim 26 , wherein the rhinitis symptom relieved comprises nasal congestion.
35 . The composition of claim 26 , wherein the rhinitis symptom relieved comprises sinus pressure.
36 . The composition of claim 26 , wherein the rhinitis symptom relieved comprises sinus pain.
37 . The composition of claim 26 , wherein the rhinitis symptom relieved comprises headache.
38 . The composition of claim 26 , wherein the aqueous solution of capsicum is at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
39 . The composition of claim 26 , wherein the aqueous solution of capsicum is at a concentration of about 0.0030% to about 0.0080% w/w containing about 0.5 to about 1.5 ppm total capsaicinoids.
40 . The composition of claim 26 , comprising rosemary extract at a concentration of about 0.02% to about 0.25% w/w.
41 . The composition of claim 26 , comprising rosemary extract at a concentration of about 0.05% to about 0.10% w/w.
42 . The composition of claim 26 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
43 . A composition suitable for intranasal administration to a human in need thereof comprising:
an effective amount of an aqueous solution of capsicum at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids;
rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
wherein the composition is suitable for intranasal administration;
wherein administration of the composition relieves at least one rhinitis symptom in the human in need thereof.
44 . The composition of claim 43 , wherein the rhinitis is vasomotor rhinitis.
45 . The composition of claim 43 , wherein the rhinitis is non-allergic rhinitis.
46 . The composition of claim 43 , wherein the rhinitis is allergic rhinitis.
47 . The composition of claim 43 , wherein the rhinitis is mixed rhinitis.
48 . The composition of claim 43 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
49 . The composition of claim 43 , wherein the rhinitis is idiopathic rhinitis.
50 . The composition of claim 43 , wherein the rhinitis symptom relieved comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
51 . The composition of claim 43 , wherein the rhinitis symptom relieved comprises nasal congestion.
52 . The composition of claim 43 , wherein the rhinitis symptom relieved comprises sinus pressure.
53 . The composition of claim 43 , wherein the rhinitis symptom relieved comprises sinus pain.
54 . The composition of claim 43 , wherein the rhinitis symptom relieved comprises headache.
55 . The composition of claim 43 , wherein the aqueous solution of capsicum is at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.
56 . The composition of claim 43 , wherein the aqueous solution of capsicum is at a concentration of about 0.0030% to about 0.0080% w/w containing about 0.5 to about 1.5 ppm total capsaicinoids.
57 . The composition of claim 43 , comprising rosemary extract at a concentration of about 0.05% to about 0.10% w/w.
58 . The composition of claim 43 , comprising rosemary extract at a concentration of about 0.06% to about 0.07% w/w.
59 . A method for the treatment of rhinitis symptoms administered to a human in need thereof comprising the steps of:
administering intranasally a composition comprising an effective amount of an aqueous homeopathic dilution of capsicum to a human in need thereof; and
effecting the relief from at least one rhinitis symptom.
60 . The method of claim 59 , wherein the rhinitis is vasomotor rhinitis.
61 . The method of claim 59 , wherein the rhinitis is non-allergic rhinitis.
62 . The method of claim 59 , wherein the rhinitis is allergic rhinitis.
63 . The method of claim 59 , wherein the rhinitis is mixed rhinitis.
64 . The method of claim 59 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
65 . The method of claim 59 , wherein the rhinitis is idiopathic rhinitis.
66 . The method of claim 59 , wherein the rhinitis symptom comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
67 . The method of claim 59 , wherein the capsicum is present in the composition at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids.
68 . A method for the treatment of rhinitis symptoms administered to a human in need thereof comprising the steps of:
administering intranasally an effective amount of a composition comprising an aqueous homeopathic dilution of capsicum , and rosemary extract to a human in need thereof;
effecting the relief from at least one rhinitis symptom.
69 . The method of claim 68 , wherein the rhinitis is vasomotor rhinitis.
70 . The method of claim 68 , wherein the rhinitis is non-allergic rhinitis.
71 . The method of claim 68 , wherein the rhinitis is allergic rhinitis.
72 . The method of claim 68 , wherein the rhinitis is mixed rhinitis.
73 . The method of claim 68 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
74 . The method of claim 68 , wherein the rhinitis is idiopathic rhinitis.
75 . The method of claim 68 , wherein the rhinitis symptom comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
76 . The method of claim 68 , wherein the capsicum is present in the composition at a concentration of about 0.00060% to about 0.010% w/w containing about 0.1 to about 2.0 ppm total capsaicinoids.
77 . The method of claim 68 , wherein the rosemary extract is present in the composition at a concentration of about 0.02% to about 0.25% w/w.
78 . A method for the treatment of rhinitis symptoms administered to a human in need thereof comprising the steps of:
administering intranasally an effective amount of a composition comprising about 0.00060% to about 0.010% w/w capsicum containing about 0.1 to about 2.0 ppm total capsaicinoids, and rosemary extract at a concentration of about 0.02% to about 0.25% w/w;
effecting the relief from at least one rhinitis symptom.
79 . The method of claim 78 , wherein the rhinitis is vasomotor rhinitis.
80 . The method of claim 78 , wherein the rhinitis is non-allergic rhinitis.
81 . The method of claim 78 , wherein the rhinitis is allergic rhinitis.
82 . The method of claim 78 , wherein the rhinitis is mixed rhinitis.
83 . The method of claim 78 , wherein the rhinitis is allergic rhinitis with a non-allergic component.
84 . The method of claim 78 , wherein the rhinitis is idiopathic rhinitis.
85 . The method of claim 78 , wherein the rhinitis symptom comprises at least one of nasal congestion, sinus pressure, sinus pain, headache or a combination thereof.
86 . The method of claim 78 , wherein the capsicum is present in the composition at a concentration of about 0.0020% to about 0.0080% w/w containing about 0.3 to about 1.5 ppm total capsaicinoids.