Anti-inflammatory dissolvable film
View Patent ↗Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.
1. A method of treating an indication of mucosa tissue comprising administering to the affected mucosal tissue a dissolvable film comprising: a) an antiinflammatory amount of an extract of Sambucus nigra and one or more of a
second extract of Calendula officinalis, Allium sativum, Camellia sinensis, Centella asiatica, Commiphora molmol, Echinacea purpurea, Gaultheria procumbens,
Hypericum perforatum, Krameria triandra, Ligusticum porterii - osha, Matricaria recutita, Melissa officinalis, Salix alba, Thymus vulgaris, Uncaria tomentosa, Usnea barbata or Vaccinium myrtillus;
b) an adhesive layer comprising:
50% or more by weight polymer(s) comprising an adhesion-promoting amount of carbamer and one or more soluble polymers,
wherein the adhesive layer becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom, and the adhesion of the adhesive layer is less aggressive than would pertain for an adhesive layer consisting of polymers including 40% or more by weight of Carbopol 940 and said antiinflammatory amount of said extracts,
and wherein the extracts are substantially comprised in the adhesive layer; and
c) a less adhesive protective layer, wherein the protective layer has polymers selected
to be, on the whole, relatively less dissolvable than those of adhesive layer;
wherein the film, when placed on a mucosal surface, dissolves away completely after 15 minutes or more and dissolution is such that such film can be applied to a mucosal lesion two or more times per day without film removal from the lesion,
wherein the film has only the two layers, and wherein the film, if periodically applied to
the mucosal indication, is effective in ameliorating said indication.
2. The method of claim 1 , wherein the indication is of the oral cavity.
3. The method of claim 2 , wherein the indication is periodontal disease, mechanical trauma, thermal trauma, xerostomia, mucositis, eruptions of lichen planus, bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis or angular chelitis, microbial eruptions of the oral mucosa, lesions resulting from trauma, lesions secondary to systemic disease, or lesions resulting from autoimmune disease.
4. The method of claim 2 , wherein the indication is periodontal disease.
5. The method of claim 2 , wherein the indication is gingivitis.
6. The method of claim 2 , wherein the indication is eruptions of lichen planus, bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis or angular chelitis.
7. The method of claim 2 , wherein the indication is a lesion resulting from trauma.
8. The method of treating an indication of the mucosa of claim 1 , wherein the mucosa is anal or vaginal mucosa, and wherein the film, if periodically applied to the indication of anal or vaginal mucosa, is effective in ameliorating said indication.
9. The method of claim 8 , wherein in the film dissolves away completely after 30 minutes or more.
10. The method of claim 8 , wherein in the film said extracts of Sambucus nigra comprises 51 to 100% by weight of the extracts in the film.
11. The method of claim 10 , wherein in the film the second extract comprises from 1 to 50% by weight of extracts in the film.
12. The method of claim 11 , wherein in the film there is a third extract that comprises from 0.5 to 5% by weight of extracts in the film.
13. The method of claim 12 , wherein the third extract is of Centella asiatica.
14. The method of claim 10 , wherein in the film the second extract is of Calendula officinalis and comprises from 1 to 50% by weight of extracts in the film.
15. The method of claim 14 , wherein in the film there is a third extract that comprises from 0.5 to 5% by weight of extracts in the film.
16. The method of claim 15 , wherein the third extract is of Centella asiatica.
17. The method of claim 8 , the film further comprising one or more non-herbal anti-inflammatory agents.
18. The method of claim 8 , wherein the film comprises an antiinflammatory effective amount of component(s) of Sambucus nigra and Calendula officinalis.
19. The method of claim 8 , wherein the film comprises an antiinflammatory
effective amount of component(s) of Sambucus nigra, Calendula officinalis and Centella asiatica.