METHODS FOR REDUCING OR NEOVASCULARIZATION OR EDEMA
Methods for reducing or preventing neovascularization or edema in the eye by implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
1 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 50% by weight of dexamethasone and about 50% by weight of polylactic polyglycolic acid (PLGA).
2 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 70% by weight of dexamethasone and about 30% by weight of polylactic polyglycolic acid (PLGA).
3 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 50% by weight of dexamethasone, about 15% by weight of hydroxypropyl methylcellulose (HPMC), and about 35% by weight of Resomer RG 502H PLGA.
4 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 60% by weight of dexamethasone, about 30% by weight of Resomer RG 502H PLGA, and about 10% by weight of Resomer RG 502 PLGA.