Medical apparatus and method for producing same
View Patent ↗A medical device that includes at least one antibiotic in a macromolecular substance that swells upon contact with a solvent. Also, a method for preparing an antibiotic-containing medical device that involves contacting a medical device having at least a portion of the surface formed from a swellable macromolecular substance, with a solvent that swells the macromolecular substance, contacting the swollen macromolecular substance with at least one antibiotic, and removing the solvent from the swollen macromolecular substance.
1. A method for preparing an antibiotic-containing medical device comprising:
providing a medical device having at least a portion of the surface formed from a swellable macromolecular substance; swelling said macromolecular substance by contacting it with an aprotic polar solvent; then contacting the swollen macromolecular substance with at least one water-soluble antibiotic dissolved in an aqueous solution; and removing residual solvent.
2. The method of claim 1 wherein the medical device comprises a synthetic resin.
3. The method of claim 2 wherein the synthetic resin is selected from the group consisting of a polyurethane, a polyamide, and combinations thereof.
4. The method of claim 1 wherein the aprotic polar solvent is selected from the group consisting of dimethylformamide, dimethyl sulphoxide, dimethylacetamide, 2-butanone, acetone, acetonitrile, N-methylpyrrolidone, and combinations thereof.
5. The method of claim 1 wherein the water soluble antibiotic is selected from the group consisting of isepamicin sulphate, amikacin sulphate, tobramycin, kitasamycin tartrate, and combinations thereof.
6. The method of claim 1 , wherein the antibiotic is retained within the macromolecular substance.
7. The method of claim 1 , wherein at least a portion of the macromolecular substance comprises a meshwork structure, and the antibiotic is retained in said meshwork structure.
8. The method of claim 1 wherein the solvent is removed from the swollen macromolecular substance by a method selected from the group consisting of drying, washing, and combinations thereof.