Alkoxysilane derivatives of N-acyl amino acids, N-acyl dipeptides, and N-acyl tripeptides, and particles and stable oil-in-water formulations using the same
View Patent ↗Hydrophilic N-acylamino acid, N-acyl dipeptide, and N-acyl tripeptide substituted silanes are prepared which can be utilized as reactive surface treatments for particles of pigments, minerals, and fillers. These treated particles form stable dispersions in the aqueous phase of oil-in-water mixtures that are suitable for cosmetic applications. The treated particles may also be used in pressed powder and color cosmetic formulations.
1. A particle of a mineral, filler, or pigment having on its surface a coating of a hydrophilic alkoxysilane derivative of an N-acylamino acid, N-acyl dipeptide, or N-acyl tripeptide, wherein the acyl group contains fewer than six carbon atoms, and wherein the derivative forms a covalent bond with a surface of the particle via an oxane bridge between a silicon atom in the silane and the particle, and wherein the covalent bonding provides for the formation of stable oil-water systems.
2. The particle according to claim 1 , wherein the acyl group is acetyl.
3. The particle according to claim 1 , wherein the alkoxy group is selected from the group consisting of methoxy and ethoxy.
4. The particle according to claim 1 , wherein the derivative is a propyltrialkoxysilane derivative.
5. The particle according to claim 1 , wherein the derivative is (N-acetylglycylpropyl)triethoxysilane.
6. The particle according to claim 1 , wherein the derivative is (N-acetylglycinamidepropyl) trimethoxysilane.
7. The particle according to claim 1 , wherein the derivative is (N-acetylleucinamidepropyl) triethoxysilane.
8. The particle according to claim 1 , wherein the derivative is (N-acetylhydroxyprolyl)propyltriethoxysilane.
9. The particle according to claim 1 , wherein the particle has a dimension no greater than about 200 microns in a largest dimension and no less than about 0.01 microns in the smallest dimension.
10. An oil-in-water formulation containing a dispersion comprising particles of a mineral, filler, and/or pigment having on its surface a coating of a hydrophilic alkoxysilane derivative of an N-acylamino acid, N-acyl dipeptide, or N-acyl tripeptide, wherein the acyl group contains fewer than six carbon atoms, and wherein the derivative forms a covalent bond with a surface of the particle via an oxane bridge between a silicon atom in the silane and the particle.
11. A pressed powder or color cosmetic comprising particles of a mineral, filler, and/or pigment having on its surface a coating of a hydrophilic alkoxysilane derivative of an N-acylamino acid, N-acyl dipeptide, or N-acyl tripeptide, wherein the acyl group contains fewer than six carbon atoms, and wherein the derivative forms a covalent bond with a surface of the particle via an oxane bridge between a silicon atom in the silane and the particle.