Multi-Purpose Bio-Material Composition
The present invention relates to a multi-purpose bio-material. One preferred embodiment of the present invention generally comprises KH 2 PO 4 , a metal oxide (i.e., MgO), a calcium-containing compound, a sugar and water. Exemplary calcium containing compounds include but are not limited to tri-calcium phosphates. The invented compositions has shown excellent adhesive properties as well as surprising and significant osteoproliferative properties.
1 . An osteoproliferative bio-material composition comprising:
a phosphoric acid or phosphoric acid salt;
a metal oxide;
a calcium containing compound; and
a sugary compound selected from the group selected from the group consisting of sugars, sugar alcohols, sugar acids, amino sugars, glycosaminoglycans, glycolipids, sugar substitutes and combinations thereof.
2 . The bio-material composition of claim 1 , further comprising water.
3 . The bio-material composition of claim 1 , wherein the weight ratio between the phosphoric acid or phosphoric acid salt and the metal oxide is between about 2:1 and 1:1.
4 - 5 . (canceled)
6 . The bio-material composition as recited in claim 1 , wherein the calcium containing compound is Ca 10 (PO 4 ) 6 (OH) 2 .
7 . (canceled)
8 . The bio-material composition as recited in claim 1 , wherein the sugary compound is a sugar.
9 . (canceled)
10 . The bio-material composition of claim 1 , wherein the metal oxide is MgO.
11 . The bio-material composition of claim 1 , wherein:
the phosphoric acid or phosphoric acid salt is present at between about 40 and 65 dry weight percent;
the metal oxide is present at between about 30 and 50 dry weight percent;
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugary compound is present at between 0.5 and 20 dry weight percent.
12 . The bio-material composition of claim 1 , wherein:
the phosphoric acid or phosphoric acid salt is present at between about 20 and 70 dry weight percent;
the metal oxide is present at between about 10 and 50 dry weight percent;
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugary compound is present at between 0.5 and 20 dry weight percent.
13 . (canceled)
14 . An osteoproliferative bio-material composition comprising:
KH 2 PO 4 ,
a metal oxide,
a tri-calcium phosphate and
a sugary compound selected from the group selected from the group consisting of sugars, sugar alcohols, sugar acids, amino sugars, glycosaminoglycans, glycolipids, sugar substitutes and combinations thereof.
15 . The bio-material composition of claim 14 , wherein the weight ratio between the KH 2 PO 4 and the metal oxide is between about 2:1 and 1:1.
16 . The bio-material composition of claim 14 , wherein the metal oxide is MgO.
17 . The bio-material composition of claim 14 , wherein the composition is osteoinductive.
18 . The bio-material composition of claim 14 , wherein the tri-calcium phosphate is Ca 10 (PO 4 ) 6 (OH) 2 .
19 . (canceled)
20 . The bio-material composition of claim 14 , wherein the sugary compound is a sugar.
21 - 22 . (canceled)
23 . The bio-material composition of claim 14 , wherein:
the KH 2 PO 4 is present at between about 40 and 50 dry weight percent;
the metal oxide is present at between about 35 and 50 dry weight percent;
the tri-calcium phosphate is present at between about 1 and 15 dry weight percent; and
the sugary compound is present at between 0.5 and 10 dry weight percent.
24 . The bio-material composition as recited in claim 14 , further comprising a sodium phosphate.
25 . An osteoproliferative bio-material composition comprising a dry phase consisting of the bio-material composition of claim 14 , and an aqueous phase.
26 . (canceled)
27 . A method for promoting hard tissue growth comprising applying a bio-material according to claim 1 to a tissue or hard tissue defect.
28 - 30 . (canceled)
31 . A method for promoting hard tissue growth comprising applying a bio-material to a tissue or hard tissue defect, wherein the bio-material is a mixture of the composition of claim 12 and an aqueous solution.
32 - 33 . (canceled)
34 . A method for attaching an object to bone comprising affixing the object to the bone with the bio-material composition of claim 1 .