Delivery devices with coolable energy emitting assemblies

1. A method of treating tissue in an airway of a bronchial tree of a subject, comprising:

moving an energy delivery device along a passageway in the airway, the passageway being defined by an inner surface of the airway;

delivering energy through the inner surface from the energy delivery device to damage a target region of tissue radially outward from the inner surface, the target region having a temperature profile; and

modifying the temperature profile during energy delivery such that the damaged target region has a maximum cross-sectional width at a first location which is radially separated from the inner surface of the airway relative to a longitudinal axis of the airway to maintain a protected region, in which a majority of the tissue is not permanently damaged, between the target region and the inner surface of the airway,

wherein the target region includes at least a portion of a nerve trunk extending along the airway, the energy delivery device being configured to sufficiently damage the nerve trunk to attenuate nervous system signals transmitted to a portion of the bronchial tree distally of the target region.

2. The method of claim 1 , wherein the maximum cross-sectional width of the target region is located at least 2 mm radially outward from the inner surface.

3. The method of claim 1 , wherein the first location is radially outward from a smooth muscle tissue region of the tissue.

4. The method of claim 1 , wherein a majority of the target region is outside a region of smooth muscle tissue of the tissue.

5. The method of claim 1 , wherein the airway is hyper-responsive or constricted, and wherein the energy is delivered such that any damage to the smooth muscle tissue of the airway is less than that required to substantially alter the responsiveness or constriction of the airway.

6. The method of claim 1 , wherein modifying the temperature profile during energy delivery includes maintaining a protected region in which a majority of the tissue is not permanently damaged, and wherein the protected region is between the target region and the inner surface of the airway.

7. The method of claim 1 wherein maintaining the protected region comprises cooling the protected region with a cooling section of the energy delivery device while the energy is delivered.

8. The method of claim 7 wherein the cooling section comprises an inflatable member.

9. The method of claim 1 , wherein delivering energy to the tissue comprises delivering the energy from a cooled electrode.

10. A method of treating tissue in an airway of a bronchial tree of a subject, comprising:

moving an energy delivery device along a passageway in the airway, the passageway being defined by an inner surface of the airway; and

delivering energy through the inner surface from the energy delivery device to damage a target region of tissue radially outward from the inner surface such that the damaged target region has a maximum cross-sectional width at a first location which is radially separated from the inner surface of the airway

wherein the target region includes at least a portion of a nerve trunk extending along the airway, the energy delivery device being configured to sufficiently damage the nerve trunk to attenuate nervous system signals transmitted to a portion of the bronchial tree distally of the target region, and

wherein the airway is hyper-responsive or constricted, and wherein the energy is delivered such that any damage to the smooth muscle tissue of the airway is less than that required to substantially alter the responsiveness or constriction of the airway.

11. The method of claim 10 , wherein the maximum cross-sectional width of the target region is located at least 2 mm radially outward from the inner surface.

12. The method of claim 10 , wherein the first location is radially outward from a smooth muscle tissue region of the tissue.

13. The method of claim 10 , wherein a majority of the target region is outside a region of smooth muscle tissue of the tissue.

14. The method of claim 10 , wherein delivering energy to the tissue comprises delivering the energy from a cooled electrode.

15. A method of treating tissue in an airway of a bronchial tree of a subject, comprising:

moving an energy delivery device along a passageway in the airway, the passageway being defined by an inner surface of the airway;

delivering energy through the inner surface from the energy delivery device to damage a target region of tissue radially outward from the inner surface such that the damaged target region has a maximum cross-sectional width at a first location which is radially separated from the inner surface of the airway, wherein the target region includes at least a portion of a nerve trunk extending along the airway, the energy delivery device being configured to sufficiently damage the nerve trunk to attenuate nervous system signals transmitted to a portion of the bronchial tree distally of the target region; and

maintaining a protected region in which a majority of the tissue is not permanently damaged, and wherein the protected region is between the target region and the inner surface of the airway.

16. The method of claim 15 , wherein maintaining the protected region comprises cooling the protected region with a cooling section of the energy delivery device while the energy is delivered.

17. The method of claim 16 , wherein the cooling section comprises an inflatable member.

18. The method of claim 15 , wherein the maximum cross-sectional width of the target region is located at least 2 mm radially outward from the inner surface.

19. The method of claim 15 , wherein the first location is radially outward from a smooth muscle tissue region of the tissue.

20. The method of claim 15 , wherein a majority of the target region is outside a region of smooth muscle tissue of the tissue.

21. The method of claim 15 , wherein delivering energy to the tissue comprises delivering the energy from a cooled electrode.