Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives

1. A pharmaceutical composition comprising:

a) a compound of Formula (I)

wherein

A is

where N is bonded to L;

L is a hydrocarbyl moiety of 1 to 6 carbon atoms optionally substituted with one or more substituents selected from the group consisting of lower alkyl, amino, hydroxy, lower alkoxy, lower alkylamino, lower alkylhio, and oxo; and

B is —OZ or N(Y 1 )-D, where Z is hydrogen or alkyl and Y 1 is hydrogen or alkyl which, when taken with D, can form a cyclic 5- or 6-membered saturated structure which can contain one other heteroatom which can be O, N, or S, of which N can be further substituted with Y 2 , where Y 2 is alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkanoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, aralkylsulfonyl, heteroaralkylsulfonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, aralkoxycarbonyl, heteroaralkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl, aralkylaminocarbonyl, or heteroaralkylaminocarbonyl, in which the alkyl portions can be cyclic and can contain from 1 to 3 heteroatoms which can be N, O, or S; and

b) a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1 , wherein L has the structure —(CH 2 ) n — wherein n is an integer from 1 to 6.

3. The pharmaceutical composition of claim 2 , wherein n is 2.

4. The pharmaceutical composition of claim 1 , wherein the moiety B is N(Y 1 )-D.

5. The pharmaceutical composition of claim 4 , wherein Y 1 is hydrogen.

6. The pharmaceutical composition of claim 4 , wherein Y 1 is lower alkyl.

7. The pharmaceutical composition of claim 6 , wherein Y 1 is methyl.

8. The pharmaceutical composition of claim 1 , wherein D is

9. The pharmaceutical composition of claim 5 , wherein D is

10. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a preservative.

11. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a stabilizing agent.

12. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a wetting agent.

13. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises an emulsifying agent.

14. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a buffering agent.

15. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises an antioxidant.

16. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a suspending agent.

17. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a thickening agent.

18. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a solubilizer.

19. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a bacteriostatic agent.

20. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is an oral formulation.

21. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is a parenteral formulation.

22. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is a solid formulation.

23. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is a liquid formulation.

24. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is a suspension formulation.

25. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is an aerosol formulation.

26. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is an injection formulation.