COMPOSITIONS FOR BOWEL PREPARATION AND METHODS OF USE THEREOF
The present invention relates to formulations and kits for gastrointestinal cleansing and to therapeutic methods thereof.
1 . A method of cleansing the GI tract of a subject, comprising:
administering about 48 mg of sodium phosphate with about 2 L of aqueous solution to a subject who has not recently had a kidney biopsy indicating kidney damage due to excess phosphate.
2 . A method of cleansing the GI tract of a subject, comprising:
determining weather a subject is a candidate for a sodium phosphate GI cleanser;
providing about 48 mg of sodium phosphate to a subject; and
instructing the subject to ingest the sodium phosphate with 2 L of aqueous solution.
3 . The method of claim 2 , wherein determining comprises a biopsy of the kidney, wherein if the biopsy shows damage to the kidney due to too much phosphate, the subject is not a candidate for a sodium phosphate GI cleanser.
4 . A method of determining if a subject is a candidate for cleansing the GI tract with sodium phosphate comprising:
determining the phosphate levels in a kidney of the subject;
wherein normal levels of phosphate in the kidney indicates that the subject is a candidate for cleansing of the GI tract with sodium phosphate.
5 . The method of claim 4 , wherein a biopsy is performed to obtain a sample of the kidney from the subject.
6 . The method of claim 4 , further comprising administering to a subject determined to be a candidate about 48 mg of sodium phosphate with about 2 L of aqueous solution.
7 . A method of determining if a subject is a candidate for cleansing the GI tract with sodium phosphate comprising:
determining if the subject has normal renal function;
wherein normal renal function indicates that the subject is a candidate for cleansing of the GI tract with sodium phosphate.
8 . The method of claim 7 , wherein normal renal function is characterized by creatinine clearance of greater than or equal to 30 mL/minute.
9 . The method of claim 8 , wherein further comprising administering to a subject determined to be a candidate about 48 mg of sodium phosphate with about 2 L of aqueous solution.
10 . A method of determining if a subject is a candidate for cleansing the GI tract with sodium phosphate comprising:
determining if the subject is a candidate for sodium phosphate purgative cleansing by one or more of: determining age, determining renal function, or determining phosphate level of the kidney; and
administering to a subject determined to be a candidate about 48 mg of sodium phosphate with about 2 L of aqueous solution.
11 . The method of claim 10 , wherein if a subject is determined to be of increased age, they are not a candidate.
12 . The method of claim 10 , wherein determined to have abnormal levels of phosphate in the kidney they are not a candidate.
13 . The method of claim 10 , if a subject has renal function characterized by creatinine clearance of greater than or equal to 30 mL/minute they are a candidate.