IP Library › Granted Patent US 8,871,202
Granted Patent B2
US 8,871,202 · App. 13/246,704 · Granted Oct 28, 2014

Prevention and treatment of pain using antibodies to sphingosine-1-phosphate

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Quick Facts
Patent No.
US 8,871,202
App. No.
13/246,704
Granted
Oct 28, 2014
Kind
B2
Abstract

The present invention relates to use of anti-S1P agents, for example, humanized monoclonal antibodies, for prevention and/or treatment of pain, including neuropathic pain, hyperalgesia, allodynia, and chemotherapy-induced pain.

Claims (4)

1. A method of reducing, or reducing the development of, neuropathic pain, allodynia or hyperalgesia in a human subject, comprising administering to a human subject having or believed to be at risk of having pain an antibody or fragment thereof that binds and neutralizes sphingosine-1-phosphate (S1P), thereby reducing, or reducing the development of, neuropathic pain.

2. The method of claim 1 wherein the neuropathic pain is chemotherapeutic drug-induced neuropathic pain.

3. The method of claim 1 wherein the antibody is a monoclonal antibody.

4. The method of claim 3 wherein the antibody is a humanized antibody.

Assignments (7)
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 5, 2023
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; LPATH THERAPEUTICS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 063264/0046 →
RELEASE OF SECURITY INTEREST Recorded Dec 30, 2021
From: SLR INVESTMENT CORP. (F/K/A SOLAR CAPITAL LTD.)
To: APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; APOLLO ENDOSURGERY, INC.; LPATH THERAPEUTICS INC.
Reel/Frame 058599/0297 →
SECURITY INTEREST Recorded Dec 23, 2021
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC. (F/K/A LPATH, INC.)
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 058980/0199 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 15, 2019
From: APOLLO ENDOSURGERY, INC.
To: SOLAR CAPITAL LTD., AS COLLATERAL AGENT
Reel/Frame 048885/0621 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 048622/0358 →
CHANGE OF NAME Recorded Mar 27, 2017
From: LPATH, INC.
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 042097/0896 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0766 →