INTERFERON-BETA FOR USE AS MONOTHERAPY OR IN COMBINATION WITH OTHER CANCER THERAPIES
This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.
1 . A method of treating melanoma in a subject, the method comprising:
identifying a subject diagnosed with melanoma;
administering an inhibitor of a protein kinase in the Ras-Raf-MEK-ERK pathway to the subject; and
administering an interferon beta to the subject.
2 . The method of claim 1 , wherein the inhibitor is an inhibitor of MEK.
3 . The method of claim 1 , wherein the inhibitor is N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide.
4 . The method of claim 1 , wherein the interferon beta is an interferon beta 1a.
5 . The method of claim 4 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
6 . The method of claim 1 , wherein the interferon beta is an interferon beta 1b.
7 . The method of claim 6 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
8 . A method of treating melanoma in a subject, the method comprising:
identifying a subject diagnosed with melanoma;
administering an alkylating agent to the subject; and
administering an interferon beta to the subject.
9 . The method of claim 8 , wherein the alkylating agent is 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide.
10 . The method of claim 8 , wherein the interferon beta is an interferon beta 1a.
11 . The method of claim 10 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
12 . The method of claim 8 , wherein the interferon beta is an interferon beta 1b.
13 . The method of claim 12 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
14 . A method of treating renal cell carcinoma in a subject, the method comprising:
identifying a subject diagnosed with renal cell carcinoma;
administering an anti-VEGF antibody to the subject; and
administering an interferon beta to the subject.
15 . The method of claim 14 , wherein the anti-VEGF antibody is a humanized monoclonal anti-VEGF-A antibody.
16 . The method of claim 14 , wherein the interferon beta is an interferon beta 1a.
17 . The method of claim 14 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
18 . The method of claim 14 , wherein the interferon beta is an interferon beta 1b.
19 . The method of claim 18 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
20 . A method of treating renal cell carcinoma in a subject, the method comprising:
identifying a subject diagnosed with renal cell carcinoma;
administering an inhibitor of mTOR to the subject; and
administering an interferon beta to the subject.
21 . The method of claim 20 , wherein the inhibitor of mTOR is temsirolimus.
22 . The method of claim 20 , wherein the interferon beta is an interferon beta 1a.
23 . The method of claim 22 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
24 . The method of claim 20 , wherein the interferon beta is an interferon beta 1b.
25 . The method of claim 24 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
26 . A method of treating renal cell carcinoma in a subject, the method comprising:
identifying a subject diagnosed with renal cell carcinoma;
administering an inhibitor of Raf-1 to the subject; and
administering an interferon beta to the subject.
27 . The method of claim 26 , wherein the inhibitor of Raf-1 is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide.
28 . The method of claim 26 , wherein the interferon beta is an interferon beta 1a.
29 . The method of claim 28 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
30 . The method of claim 26 , wherein the interferon beta is an interferon beta 1b.
31 . The method of claim 30 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
32 . A method of treating colon carcinoma in a subject, the method comprising:
identifying a subject diagnosed with colon carcinoma;
administering an anti-VEGF antibody to the subject; and
administering an interferon beta to the subject.
33 . The method of claim 32 , wherein the anti-VEGF antibody is a humanized monoclonal anti-VEGF-A antibody.
34 . The method of claim 32 , wherein the interferon beta is an interferon beta 1a.
35 . The method of claim 34 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
36 . The method of claim 32 , wherein the interferon beta is an interferon beta 1b.
37 . The method of claim 36 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
38 . A method of treating breast carcinoma in a subject, the method comprising:
identifying a subject diagnosed with breast carcinoma;
administering a mitotic inhibitor to the subject; and
administering an interferon beta to the subject.
39 . The method of claim 38 , wherein the mitotic inhibitor is paclitaxel.
40 . The method of claim 38 , wherein the interferon beta is an interferon beta 1a.
41 . The method of claim 40 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
42 . The method of claim 38 , wherein the interferon beta is an interferon beta 1b.
43 . The method of claim 42 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
44 . A method of treating breast carcinoma in a subject, the method comprising:
identifying a subject diagnosed with breast carcinoma; and
administering an interferon beta to the subject.
45 . The method of claim 44 , wherein the interferon beta is an interferon beta 1a.
46 . The method of claim 45 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
47 . The method of claim 44 wherein the interferon beta is an interferon beta 1b.
48 . The method of claim 47 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
49 . A method of treating melanoma in a subject, the method comprising:
identifying a subject diagnosed with melanoma; and
administering an interferon beta to the subject.
50 . The method of claim 49 , wherein the interferon beta is an interferon beta 1a.
51 . The method of claim 50 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
52 . The method of claim 49 , wherein the interferon beta is an interferon beta 1b.
53 . The method of claim 52 , wherein the interferon beta 1a is a pegylated interferon beta 1b.
54 . A method of treating renal cell carcinoma in a subject, the method comprising:
identifying a subject diagnosed with renal cell carcinoma; and
administering an interferon beta to the subject.
55 . The method of claim 54 , wherein the interferon beta is an interferon beta 1a.
56 . The method of claim 55 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
57 . The method of claim 54 , wherein the interferon beta is an interferon beta 1b.
58 . A method of treating colon carcinoma in a subject, the method comprising:
identifying a subject diagnosed with colon carcinoma; and
administering an interferon beta to the subject.
59 . The method of claim 58 , wherein the interferon beta is an interferon beta 1a.
60 . The method of claim 59 , wherein the interferon beta 1a is a pegylated interferon beta 1a.
61 . The method of claim 58 , wherein the interferon beta is an interferon beta 1b.