IP Library Granted Patent US 8,370,077
Granted Patent B2
US 8,370,077 · App. 13/251,356 · Granted Feb 5, 2013

System for optimizing a patient's insulin dosage regimen

Inventors: Eran Bashan (Ann Arbor, MI); Israel Hodish (Ann Arbor, MI)
Assignee: Hygieia, Inc.
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Quick Facts
Patent No.
US 8,370,077
App. No.
13/251,356
Granted
Feb 5, 2013
Kind
B2
Abstract

A system for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range.

Claims (20)

1. A method for updating a patient's insulin dosage regimen, the method comprising:

storing one or more components of the patient's insulin dosage regimen;

initiating a timer to monitor a predetermined time period;

measuring the patient's blood glucose-level at a plurality of times during the predetermined time period;

obtaining data corresponding to the patient's blood glucose-level measurements determined at the plurality of times;

incrementing the timer based on at least one of the passage of a predetermined increment of time and the receipt of at least one of the plurality of blood glucose-level measurements;

tagging the plurality of blood glucose-level measurements with an identifier reflective of when the measurement was obtained;

determining, after obtaining one of the plurality of blood glucose-level measurements but before obtaining a subsequent blood glucose-level measurement, whether the obtained blood glucose-level measurement reflects a hypoglycemic event or a severe hypoglycemic event;

reducing at least one of the one or more components in the patient's insulin dosage regimen in response to the determination that the most recently obtained blood glucose-level measurement represents a severe hypoglycemic event;

reducing at least one of the one or more components in the patient's insulin dosage regimen in response to a determination that the most recently obtained blood glucose-level measurement results in an excessive number of hypoglycemic events during the predetermined time period; wherein the timer is reinitiated after the determination that there have been an excessive number of hypoglycaemic events over the predetermined amount of time; and

determining, at the end of the predetermined time period, from a plurality of the data corresponding to the patient's blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patients present insulin dosage regimen in order to maintain the patient's blood glucose-level measurements within a predefined range; wherein the timer is reinitiated after the determination of whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen.

2. The method of claim 1 , further comprising enabling a user to modify the identifier associated with each blood-glucose-level measurement.

3. The method of claim 1 , further comprising determining on a predefined schedule whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen.

4. The method of claim 1 , further comprising:

determining from the plurality of the data corresponding to the patient's blood-glucose-level measurements if the patient's blood-glucose level measurements fall within or outside of a predefined range, and

varying at least one of the one or more components in the patient's present insulin dosage regimen only if the patient's blood-glucose level measurements fall outside of the predefined range.

5. The method of claim 1 , further comprising determining from the patient's blood-glucose-level measurements whether the patients blood-glucose-level measurements represent a normal distribution.

6. The method of claim 5 , wherein the determination of whether the patient's blood-glucose-level measurements represent a normal distribution comprises determining whether the third moment of the distribution of the patient's blood-glucose-level measurements fall within a predefined range.

7. The method of claim 1 , wherein the one or more components in the patient's present insulin dosage regimen comprise a long-acting insulin dosage component.

8. The method of claim 1 , wherein the one or more components in the patient's present insulin dosage regimen comprise a short-acting insulin dosage component defined by a carbohydrate ratio or a fixed meal dose, and plasma glucose correction factor.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 3, 2011
From: BASHAN, ERAN; HODISH, ISRAEL
To: HYGIEIA, INC.
Reel/Frame 027004/0579 →
Continuity (4)
Continuation 12417960 · Apr 3, 2009
Provisional Application 61042487 · Apr 4, 2008
Provisional Application 61060645 · Jun 11, 2008
Related Publication 20120022353A1 · Jan 26, 2012