Pleuromutilin derivatives for the treatment of diseases mediated by microbes
Disclosed are pleuromutilin derivatives of formula (I) and their use in the treatment of diseases mediated by microbes.
1. A composition comprising the compound 14-O-{[(1R, 2R, 4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin, wherein said compound has the structure of formula (I):
2. The composition of claim 1 in the form of a pharmaceutically acceptable salt.
3. The composition of claim 2 wherein said salt is selected from the group consisting of a sodium salt, a potassium salt, a calcium salt, a magnesium salt, trimethylammonium salt, an isopropylamine salt, a diethylamine salt, an ethanolamine salt, a trimethylamine salt, a dicyclohexyl amine salt, a N-methyl-D-glucamine salt, a hydrogen fumaric acid salt, a fumaric acid salt, a tartaric acid salt, an ethane-1,2-disulphonic acid salt, a naphthalin-1,5-sulphonic acid salt, an acetic acid salt, a maleic acid salt, a succinic acid salt, a salicylic acid salt, an azelaic acid salt, a 2-[(2,6-dichlorophenyl)amino]benzene acetic acid salt, and a hydrochloric acid salt.
4. The composition of claim 1 , further comprising at least one pharmaceutically acceptable excipient.
5. The composition of claim 2 , further comprising at least one pharmaceutically acceptable excipient.