Novel Coated Membranes and Other Articles
The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.
1 - 60 . (canceled)
61 . A method for removing cells from a solution comprising the steps of: providing a solution comprising having undesired cells; and filtering said solution through a clean, caustic resistant, porous membrane comprising a polyvinylidene difluoride microporous membrane substrate and a heat stable biomolecule resistant surface, wherein said heat stable biomolecule resistant surface is a separately formed surface coating which comprises a crosslinked terpolymer, said crosslinked terpolymer being a copolymer formed from either: (a) methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide; or (b) methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide.
62 . A method for sterilizing a solution comprising the steps of: providing a nonsterile solution; and filtering said solution through a clean, caustic resistant, porous membrane comprising a polyvinylidene difluoride microporous membrane substrate and a heat stable biomolecule resistant surface wherein said heat stable biomolecule resistant surface is a separately formed surface coating which comprises a crosslinked terpolymer, said crosslinked terpolymer being a copolymer formed from either: (a) methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide; or (b) methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide.
63 . A polymer membrane having a surface coating comprising at least one hydroxymethyldiacetoneacrylamide (HMDAA) monomer of formula:
wherein R 1 and R 2 are each independently H or CH 2 OH.
64 . The membrane of claim 63 wherein R 1 and R 2 are each CH 2 OH.
65 - 66 . (canceled)