IP Library Granted Patent US 8,324,281
Granted Patent B2
US 8,324,281 · App. 13/253,648 · Granted Dec 4, 2012

Topical nepafenac formulations

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Quick Facts
Patent No.
US 8,324,281
App. No.
13/253,648
Granted
Dec 4, 2012
Kind
B2
Abstract

Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.

Claims (10)

1. A topically administrable ophthalmic composition consisting of

a) 0.1% (w/v) nepafenac;

b) 0.5% (w/v) carbomer;

c) 0.001-0.05% (w/v) tyloxapol;

d) 0.3-0.5% (w/v) sodium chloride;

e) 2-3% (w/v) mannitol;

f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH from 7.3-7.7;

g) 0.001-0.01% (w/v) benzalkonium chloride;

h) 0.001-0.1% (w/v) edetate disodium; and

i) water.

Assignments (6)
SECURITY INTEREST Recorded Sep 26, 2025
From: HARROW, INC.; HARROW IP, LLC
To: FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 072384/0781 →
RELEASE OF SECURITY INTEREST Recorded Sep 18, 2025
From: OAKTREE FUND ADMINISTRATION, LLC, AS ADMINISTRATIVE AGENT
To: HARROW IP, LLC
Reel/Frame 072299/0911 →
PATENT SECURITY AGREEMENT Recorded Mar 30, 2023
From: HARROW IP, LLC
To: OAKTREE FUND ADMINISTRATION, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 063205/0708 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 62452/0106 Recorded Mar 30, 2023
From: B. RILEY COMMERCIAL CAPITAL, LLC, AS ADMINISTRATIVE AGENT
To: HARROW HEALTH, INC.; HARROW EYE, LLC; HARROW IP, LLC; IMPRIMISRX, LLC; IMPRIMIS NJOF, LLC; IMPRIMISRX NJ, LLC; VISIONOLOGY EQUITY, LLC; VISIONOLOGY, INC.; VISIONOLOGY MSO, INC.
Reel/Frame 063206/0156 →
SECURITY INTEREST Recorded Jan 23, 2023
From: HARROW HEALTH, INC.; HARROW IP, LLC; IMPRIMISRX, LLC; HARROW EYE, LLC; IMPRIMIS NJOF, LLC; IMPRIMISRX NJ, LLC; VISIONOLOGY EQUITY, LLC; VISIONOLOGY, INC.; VISIONOLOGY MSO, INC.
To: B. RILEY COMMERCIAL CAPITAL, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 062452/0106 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2023
From: NOVARTIS AG
To: HARROW IP, LLC
Reel/Frame 062442/0255 →