Injectable biomaterials
View Patent ↗Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.
1. An injectable composition formed from tropoelastin, the composition comprising:
(a) a tropoelastin containing substance having a tropoelastin concentration of from 5 mq/mL to 300 mq/mL and
(b) an agent selected from hyaluronic acid, carboxymethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose, in an amount from 0.5% to 2.0% w/v, wherein the amount of agent is effective for providing the substance with properties of flow enabling injection of the composition.
2. The composition of claim 1 wherein the substance is in the form of a non particulate mass.
3. The composition of claim 1 wherein the agent is hyaluronic acid.
4. The composition of claim 1 wherein the agent is carboxymethylcellulose.
5. The composition of claim 1 wherein the agent is hydroxypropylcellulose.
6. The composition of claim 1 wherein the agent is hydroxypropylmethylcellulose.
7. The composition of claim 1 wherein the substance is in the form of a particulate mass.
8. The composition of claim 7 wherein the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
9. The composition of claim 8 wherein the agent is hyaluronic acid.
10. The composition of claim 8 wherein the agent is carboxymethylcellulose.
11. The composition of claim 8 wherein the agent is hydroxypropylcellulose.
12. The composition of claim 8 wherein the agent is hydroxypropylmethylcellulose.
13. The composition of claim 1 wherein the substance is in the form of globules.
14. The composition of claim 13 wherein the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
15. The composition of claim 13 wherein the agent is hyaluronic acid.
16. The composition of claim 13 wherein the agent is carboxymethylcellulose.
17. The composition of claim 13 wherein the agent is hydroxypropylcellulose.
18. The composition of claim 13 wherein the agent is hydroxypropylmethylcellulose.
19. An injectable composition for altering or correcting a tissue defect, the composition comprising:
a liquid phase comprising a plurality of globules formed from tropoelastin having a tropoelastin concentration of from 5 mg/mL to 300 mg/mL, the liquid phase having a coalescence-controlling agent selected from hyaluronic acid, carboxymethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose dissolved therein in an amount from 0.5% to 2.0% w/v, wherein the amount of coalescence-controlling agent is effective for reducing coalescence of the globules.
20. The composition of claim 19 wherein the agent is hyaluronic acid and the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
21. The composition of claim 19 wherein the agent is carboxymethylcellulose and the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
22. The composition of claim 19 wherein the agent is hydroxypropylcellulose and the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
23. The composition of claim 19 wherein the agent is hydroxypropylmethylcellulose and the mass ratio of tropoelastin to agent is about 0.2:1 to about 100:1.
24. The composition of claim 19 wherein the substance is formed from non cross linked tropoelastin.
25. The composition of claim 19 where the tropoelastin is a fragment of tropoelastin.
26. The composition of claim 19 wherein the globules are in the form of microspheres.