Apparatus for the aerosolization of large volumes of dry powder

1. A system for dosing and aerosolization of aerosolizable material, the system comprising:

a body with an aerosolization channel having a distal attachment portion connectable to a source of carrier gas which provides pressure pulses of the gas to the aerosolization channel and a proximal attachment portion for outputting aerosolized material towards a patient;

a reservoir for receiving aerosolizable material, the reservoir comprising at least one wall and being connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel;

a funnel portion tapered towards the aerosolization channel provided in the body between the reservoir and the aerosolization channel;

an additional piece of pathway for aerosol to traverse configured to introduce expansion space for the pulsed gas stream and thus allow the pressure pulse of the gas arranged to carry the aerosol to the patient to dampen, the additional piece of pathway being a first hollow spacer comprising a distal portion having at least one inner wall tapered towards the proximal attachment portion, and a proximal portion having at least one inner wall and configured to taper towards the patient, with a central cylindrical portion therebetween haying at least one inner wall, and the additional piece of pathway further being connected to the proximal attachment portion; and

a compensation tubing provided between an interior of the first hollow spacer and an interior of the funnel portion,

wherein at least one wall of the funnel portion and the at least one inner wall of the distal portion, of the central portion and/or the proximal portion of the first hollow spacer comprise self-exciting membranes that can be put into oscillation by the pressure pulses,

and wherein corresponding spaces are provided between such self-exciting membranes and an outer wall.

2. The system of claim 1 , wherein the reservoir is provided with a top cover and the top cover comprises a self-exciting membrane towards the reservoir.

3. The system of claim 1 , wherein a self-exciting membrane is provided in a wall of the aerosolization channel beneath the connection thereof with the reservoir.

4. The system of claim 1 , wherein the reservoir and the body are integrally formed.

5. The system of claim 1 , wherein the reservoir is connected with the aerosolization channel via a valve.

6. The system of claim 5 , wherein the valve is a rotary valve.

7. The system of claim 1 , wherein an annular gap is provided between the distal and the central portions of the first hollow spacer, which is connectable to an auxiliary air supply.

8. The system of claim 7 , further comprising a second hollow spacer connected proximally to the proximal portion of the first hollow spacer and distally to a mouth piece, the second hollow spacer having an ambient air inlet with a non-return valve provided at the distal end and an exhaled gas outlet provided at the proximal end of the second hollow spacer.

9. The system of claim 1 , further comprising a ventilator or a CPAP valve, wherein the proximal portion of the first hollow spacer and the ventilator or CPAP valve are connected via a Y-connector to a patient side respiratory front end.

10. The system of claim 9 , wherein an air delivery port of the ventilator and an exhaled gas port of the ventilator are connected to the Y-connector via a manifold.

11. The system of claim 10 , wherein a flow sensor is provided at the manifold, and an oxygen sensor is provided at a patient side port of the Y-connector.

12. The system of claim 9 , wherein the patient side respiratory front end is a nasopharyngeal tube.

13. The system of claim 9 , wherein the first hollow spacer is connected proximally to a respiratory front end,

wherein the first hollow spacer is further connected at its distal end via a non-return valve to an air delivery port of the ventilator, and is further connected at its proximal end to an exhaled gas port of the ventilator.

14. The system of claim 9 , wherein any one of a flow sensor and an oxygen sensor is provided between the ventilator or CPAP valve and the patient side respiratory front end.

15. The system of claim 1 , wherein the system further comprises:

a control box for providing pressure pulses of carrier gas to the aerosolization channel, the control box being connectable to a hospital compressed air supply and connected to the distal attachment portion of the body via a valve,

wherein the control box is adapted to control the number and frequency of the carrier gas pressure pulses and the flow rate of the carrier gas by controlling the valve.