IP Library › Granted Patent US 8,729,082

Granted Patent B2

US 8,729,082 · App. 13/264,627 · Granted May 20, 2014

Substituted imidazoquinoxalines

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Quick Facts

Patent No.: US 8,729,082
App. No.: 13/264,627
Granted: May 20, 2014
Kind: B2

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Abstract

The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer.

Claims (414)

1. A compound of general formula (I):

in which:

R 1 represents a C 2 -C 10 -alkyl-, halo-C 1 -C 10 -alkyl-, HO—C 1 -C 10 -alkyl-, C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, aryloxy-C 1 -C 10 -alkyl-, halo-C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, C 2 -C 10 -alkenyl-, C 2 -C 10 -alkynyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, C 1 -C 6 -alkylene-aryl-, C 1 -C 6 -alkylene-heteroaryl-, —C 1 -C 6 -alkylene-C 3 -C 10 -cycloalkyl, —C 1 -C 6 -alkylene-(3- to 10-membered hetero cycloalkyl), —C 1 -C 6 -alkylene-aryl, —C 1 -C 6 -alkylene-heteroaryl group;

wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-, halo-C 1 -C 6 -alkoxy-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered heterocycloalkyl-, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —OC(═O)—C 1 -C 6 -alkyl, —OC(═O)—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 ;

R 2 represents a —CN, —NR 9 R 10 , —OR 9 , C 2 -C 10 -alkenyl-, C 2 -C 10 -alkynyl-, aryl-, heteroaryl-, C 1 -C 6 -alkylene-aryl-, C 1 -C 6 -alkylene-heteroaryl-group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxy-, cyano-, nitro-, C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkyl-, HO—C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-, halo-C 1 -C 6 -alkoxy-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 1 -C 6 -alkyl-C(═O)N(H)—C 1 -C 6 -alkyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered hetero cycloalkyl-, —C(═O)—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —OC(═O)—C 1 -C 6 -alkyl, —OC(═O)—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 ;

R 3 , R 4 , R 5 , R 6 , R 7 :

represent, independently from each other, a hydrogen atom, a halogen atom, a hydroxy, cyano, nitro, or a group selected from: a C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl, heteroaryl, C 1 -C 6 -alkylene-aryl, C 1 -C 6 -alkylene-heteroaryl, —C 1 -C 6 -alkylene-C 3 -C 10 -cycloalkyl, or C 1 -C 6 -alkylene-3- to 10-membered heterocycloalkyl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 ;

R 8 , R 9 , R 10 :

represent, independently from each other, a hydrogen atom, a C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, HO—C 1 -C 6 -alkyl-, cyano-C 1 -C 6 -alkyl-, C 2 -C 10 -alkynyl-C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, H 2 NC(═O)—C 1 -C 6 -alkyl-, C 1 -C 6 -alkyl-N(H)C(═O)—C 1 -C 6 -alkyl-, H 2 NS(═O) 2 —C 1 -C 6 -alkyl-, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, aryl, heteroaryl, C 1 -C 6 -alkylene-aryl, —C 1 -C 6 -alkylene-heteroaryl, —C 1 -C 6 -alkylene-C 3 -C 10 -cycloalkyl, —C 1 -C 6 -alkylene-3- to 10-membered heterocycloalkyl group;

wherein said C 3 -C 10 -cycloalkyl group is optionally substituted one or more times with a halogen atom, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, HO—C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 10 -cycloalkyl, aryl, or a heteroaryl group;

wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C 1 -C 6 -alkylene-3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)—C 1 -C 6 -alkyl, —N(H)C(═O)-heteroaryl, —N(C 1 -C 6 -alkyl)C(═O)—C 1 -C 6 -alkyl, —N(H)S(═O) 2 —C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)S(═O) 2 —C 1 -C 6 -alkyl, —C(═O)NH 2 , —C(═O)N(H)—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —OC(═O)NH 2 , —OC(═O)N(H)—C 1 -C 6 -alkyl, —OC(═O)N(C 1 -C 6 -alkyl) 2 , —N(H)C(═O)O—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)O—C 1 -C 6 -alkyl, —N(H)C(═O)NH 2 , —N(H)C(═O)N(H)—C 1 -C 6 -alkyl, —N(H)C(═O)N(C 1 -C 6 -alkyl) 2 , —N(C 1 -C 6 -alkyl)C(═O)NH 2 , —N(C 1 -C 6 -alkyl)C(═O)N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl, —S(═O) 2 —C 1 -C 6 -alkyl, —S(═O) 2 NH 2 , —S(═O) 2 N(H)—C 1 -C 6 -alkyl, —S(═O) 2 N(C 1 -C 6 -alkyl), —NH 2 , —N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 ;

R 9 , R 10 , together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group;

under the proviso that:

R 1 is not —CH 2 CH 2 CH 2 OH,

—CH 2 CH 2 CH 2 O(C═O)—R a ,

—CH 2 CH 2 CH 2 O(C═O)—OR a ,

—CH 2 CH 2 CH 2 O(C═O)—CHR a NR b R c ,

in which R a , R b , R c , identical or different, are selected from the group consisting of H, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, phenyl and heteroaryl;

or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same.

2. The compound according to claim 1 , wherein:

R 1 represents a C 2 -C 10 -alkyl-, halo-C 1 -C 10 -alkyl-, HO—C 1 -C 10 -alkyl-, C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, aryloxy-C 1 -C 10 -alkyl-, halo-C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, C 2 -C 10 -alkenyl-, C 2 -C 10 -alkynyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, C 1 -C 6 -alkylene-aryl-, C 1 -C 6 -alkylene-heteroaryl-, —C 1 -C 6 -alkylene-C 3 -C 10 -cycloalkyl, —C 1 -C 6 -alkylene-(3- to 10-membered heterocycloalkyl), —C 1 -C 6 -alkylene-aryl, —C 1 -C 6 -alkylene-heteroaryl group;

R 2 represents an aryl- or heteroaryl-group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxy-, cyano-, nitro-, C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkyl-, HO—C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-, halo-C 1 -C 6 -alkoxy-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 1 -C 6 -alkyl-C(═O)N(H)—C 1 -C 6 -alkyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered heterocycloalkyl-, —C(═O)—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —OC(═O)—C 1 -C 6 -alkyl, —OC(═O)—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 ;

R 3 , R 4 , R 5 , R 6 , R 7 :

R 8 , R 9 , R 10 :

wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C 1 -C 6 -alkylene-3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)—C 1 -C 6 -alkyl, —N(H)C(═O)-heteroaryl, —N(C 1 -C 6 -alkyl)C(═O)—C 1 -C 6 -alkyl, —N(H)S(═O) 2 —C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)S(═O) 2 —C 1 -C 6 -alkyl, —C(═O)NH 2 , —C(═O)N(H)—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —OC(═O)NH 2 , —OC(═O)N(H)—C 1 -C 6 -alkyl, —OC(═O)N(C 1 -C 6 -alkyl) 2 , —N(H)C(═O)O—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)O—C 1 -C 6 -alkyl, —N(H)C(═O)NH 2 , —N(H)C(═O)N(H)—C 1 -C 6 -alkyl, —N(H)C(═O)N(C 1 -C 6 -alkyl) 2 , —N(C 1 -C 6 -alkyl)C(═O)NH 2 , —N(C 1 -C 6 -alkyl)C(═O)N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl, —S(═O) 2 —C 1 -C 6 -alkyl, —S(═O) 2 NH 2 , —S(═O) 2 N(H)—C 1 -C 6 -alkyl, —S(═O) 2 N(C 1 -C 6 -alkyl) 2 , —NH 2 , —N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 ;

R 9 , R 10 , together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group;

under the proviso that:

R 1 is not —CH 2 CH 2 CH 2 OH,

—CH 2 CH 2 CH 2 O(C═O)—R a ,

—CH 2 CH 2 CH 2 O(C═O)—OR a ,

—CH 2 CH 2 CH 2 O(C═O)—CHR a NR b R c ,

in which R a , R b , R c , identical or different, are selected from the group consisting of H, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, phenyl and heteroaryl;

or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same.

3. The compound according to claim 1 , wherein:

R 1 represents a C 2 -C 10 -alkyl-, halo-C 1 -C 10 -alkyl-, HO—C 1 -C 10 -alkyl-, C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, aryloxy-C 1 -C 10 -alkyl-, halo-C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl-, C 2 -C 10 -alkenyl-, C 2 -C 10 -alkynyl-, C 3 -C 10 -cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, C 1 -C 6 -alkylene-aryl-, C 1 -C 6 -alkylene-heteroaryl-, —C 1 -C 6 -alkylene-C 3 -C 10 -cycloalkyl, —C 1 -C 6 -alkylene-(3- to 10-membered heterocycloalkyl), —C 1 -C 6 -alkylene-aryl, —C 1 -C 6 -alkylene-heteroaryl group;

R 3 , R 4 , R 5 , R 6 , R 7 :

represent, independently from each other, a hydrogen atom, a halogen atom, a hydroxy, cyano, nitro, or a group selected from: a C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —C(═O)NR 9 R 10 , —NR 9 R 10 ; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)R 8 , —N(C 1 -C 6 -alkyl)C(═O)R 8 , —N(H)S(═O) 2 R 8 , —N(C 1 -C 6 -alkyl)S(═O) 2 R 8 , —C(═O)NR 9 R 10 , —OC(═O)NR 9 R 10 , —N(H)C(═O)OR 8 , —N(C 1 -C 6 -alkyl)C(═O)OR 8 , —N(H)C(═O)NR 9 R 10 , —N(C 1 -C 6 -alkyl)C(═O)NR 9 R 10 , —SR 8 , —S(═O)R 8 , —S(═O) 2 R 8 , —S(═O) 2 NR 9 R 10 , —NR 9 R 10 ;

R 8 , R 9 , R 10 :

wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl, 3- to 10-membered heterocycloalkyl, —C 1 -C 6 -alkylene-3- to 10-membered heterocycloalkyl, —C(═O)OH, —C(═O)O—C 1 -C 6 -alkyl, —C(═O)O—C 3 -C 10 -cycloalkyl, —N(H)C(═O)—C 1 -C 6 -alkyl, —N(H)C(═O)-heteroaryl, —N(C 1 -C 6 -alkyl)C(═O)—C 1 -C 6 -alkyl, —N(H)S(═O) 2 —C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)S(═O) 2 —C 1 -C 6 -alkyl, —C(═O)NH 2 , —C(═O)N(H)—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —OC(═O)NH 2 , —OC(═O)N(H)—C 1 -C 6 -alkyl, —OC(═O)N(C 1 -C 6 -alkyl) 2 , —N(H)C(═O)O—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)O—C 1 -C 6 -alkyl, —N(H)C(═O)NH 2 , —N(H)C(═O)N(H)—C 1 -C 6 -alkyl, —N(H)C(═O)N(C 1 -C 6 -alkyl) 2 , —N(C 1 -C 6 -alkyl)C(═O)NH 2 , —N(C 1 -C 6 -alkyl)C(═O)N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl)C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl, —S(═O) 2 —C 1 -C 6 -alkyl, —S(═O) 2 NH 2 , —S(═O) 2 N(H)—C 1 -C 6 -alkyl, —S(═O) 2 N(C 1 -C 6 -alkyl) 2 , —NH 2 , —N(H)—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 ;

R 9 , R 10 , together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group;

under the proviso that:

R 1 is not —CH 2 CH 2 CH 2 OH,

—CH 2 CH 2 CH 2 O(C═O)—R a ,

—CH 2 CH 2 CH 2 O(C═O)—OR a ,

—CH 2 CH 2 CH 2 O(C═O)—CHR a NR b R c ,

in which R a , R b , R c , identical or different, are selected from the group consisting of H, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, phenyl and heteroaryl;

or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same.

4. The compound according to claim 1 , which is selected from the group consisting of:

1-ethyl-3-[4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-phenyl]-urea

1-(2-fluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(4-methoxy-2-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(2,5-difluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-cyclopropyl-4-{4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-[4-(benzylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzamide

N-[2-(methylamino)-2-oxoethyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(pyridin-3-yl)ethyl]benzamide

N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(1-methylcyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoic acid

1-(2-fluoropyridin-3-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(2,3-difluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(3-fluoro-4-methoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-(5-methylthiophen-2-yl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-(6-methylpyridin-3-yl)imidazo[1,2-a]quinoxalin-4-amine

2-chloro-N-cyclopropyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-methyl-5-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}pyridine-2-carboxamide

N-cyclopropyl-4-{4-[(4-sulfamoylbenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(pyridin-3-yl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-propylbenzamide

N-(2-hydroxyethyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(4-sulfamoylphenyl)benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[1-(pyridin-2-yl)cyclopropyl]benzamide

1-[4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea

1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(2-fluoro-3-methoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]quinoxalin-4-amine

1-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenol

1-(1H-indol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

2-chloro-N-methyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(2-methylbenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(morpholin-4-yl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-(4-{[2-(2-oxoimidazolidin-1-yl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-{4-[(4-cyanobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{4-[(1-methyl-1H-pyrazol-3-yl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[3-(2-oxopyrrolidin-1-yl)propyl]benzamide

N-(3-carbamoylphenyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(1-methyl-1H-pyrazol-3-yl)benzamide

N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoyl)amino]phenyl}pyridine-3-carboxamide

1-(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)ethanone

1-(1H-indazol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-cyclopropyl-4-[4-(2-hydroxy-ethylamino)-imidazo[1,2-a]quinoxalin-1-yl]-benzamide

N-cyclopropyl-4-{4-[(3-methylbenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(2-methoxybenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-[4-(ethylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-[4-({4-[(methylsulfonyl)amino]phenyl}amino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-(1-benzylpiperidin-4-yl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoyl)amino]phenyl}pyridine-4-carboxamide

N-(2-methylpropyl)-1-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]quinoxalin-4-amine

1-(1H-indazol-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-cyclopropyl-4-(4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(4-methoxyphenyl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(4-sulfamoylphenyl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(2-phenoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N,N-diethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(1-hydroxypropan-2-yl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(2-methylcyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-[1-(hydroxymethyl)cyclopropyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-benzamide

1-(4-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-[4-(methylsulfanyl)phenyl]imidazo[1,2-a]quinoxalin-4-amine

1-(2-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(1H-indol-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

1-(isoquinolin-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-methyl-3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(2-methylpropyl)-1-[2-(trifluoromethyl)phenyl]imidazo[1,2-a]quinoxalin-4-amine

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenol

1-(2-fluoro-4-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

4-{4-[(3-chlorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{4-[(2-phenylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-[4-(phenylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[4-(pyrrolidin-1-yl)butyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-(4-{[2-(4-fluorophenyl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(1H-pyrazol-3-yl)benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(prop-2-yn-1-yl)benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(pyridin-4-yl)ethyl]benzamide

1-ethyl-N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoyl)amino]phenyl}-1H-pyrazole-5-carboxamide

N-(2-methylpropyl)-1-phenylimidazo[1,2-a]quinoxalin-4-amine

N-methyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(2-methylpropyl)-1-(thiophen-2-yl)imidazo[1,2-a]quinoxalin-4-amine

1-(4-ethoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-(pyridin-3-yl)imidazo[1,2-a]quinoxalin-4-amine

N-(2-methylpropyl)-1-(pyridin-4-yl)imidazo[1,2-a]quinoxalin-4-amine

N-(3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzyl)acetamide

N-cyclopropyl-4-[4-(pentylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-(4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(3-fluorophenyl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-{4-[(1,3-benzodioxol-5-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-ethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(2-carbamoylphenyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-[3-(acetylamino)phenyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(2-fluorocyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N,N-dimethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(2-methoxypyrimidin-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)(pyrrolidin-1-yl)methanone

N-(2-methylpropyl)-1-(thiophen-3-yl)imidazo[1,2-a]quinoxalin-4-amine

1-(3,4-dimethoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine

(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)methanol

2-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenol

N-(2-methylpropyl)-1-(1H-pyrazol-3-yl)imidazo[1,2-a]quinoxalin-4-amine

N-cyclopropyl-4-{4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[3-(dimethylamino)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(3-phenylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(4-{[2-(pyridin-4-yl)ethyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-({1-[4-(cyclopropylcarbamoyl)phenyl]imidazo[1,2-a]quinoxalin-4-yl}amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

N-(2-amino-2-oxoethyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(3-amino-3-oxopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-(1-cyanocyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(2-sulfamoylethyl)benzamide

N-cyclopropyl-4-[8-fluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-(4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

N-{2-[(7,8-difluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)amino]ethyl}acetamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7,8-difluoroimidazo[1,2-a]quinoxalin-4-yl}amino)propyl]carbamate

N-cyclopropyl-4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(4-{4-[(2-methoxyethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-{4-[(2-hydroxyethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(4-{[3-(1H-imidazol-1-yl)propyl]amino}-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(3-amino-3-oxopropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}-2-chloro-N-cyclopropylbenzamide

tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7-cyanoimidazo[1,2-a]quinoxalin-4-yl}amino)propyl]carbamate

N-cyclopropyl-4-{8-fluoro-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-[4-(ethylamino)-8-fluoroimidazo[1,2-a]quinoxalin-1-yl]benzamide

4-[4-(butylamino)-8-fluoroimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

1-(4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-[4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-N-cyclopropyl-4-[8-fluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-{4-[7,8-difluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-methylurea

4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclopropylbenzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-{4-[4-(benzylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-methylurea

1-(4-{7,8-dimethyl-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

4-(7-cyano-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

4-(7-cyano-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

1-[4-(7-cyano-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-4-{7-cyano-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(4-{8-fluoro-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-[4-(8-fluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(4-{7,8-difluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-[4-(butylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

N-cyclopropyl-4-{4-[(furan-2-ylmethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

1-{4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-methylurea

2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-[4-(butylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclopropylbenzamide

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-[7-cyano-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

4-{7-cyano-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-[7-cyano-4-(ethylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-[4-(butylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

4-{7-cyano-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-(4-{[2-(acetylamino)ethyl]amino}-7-cyanoimidazo[1,2-a]quinoxalin-1-yl)-2-chloro-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

1-(4-{8-fluoro-4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-[4-(ethylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]benzamide

4-(4-{[2-(acetylamino)ethyl]amino}-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

1-(4-{7,8-difluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

4-(4-{[2-(acetylamino)ethyl]amino}-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl)-2-chloro-N-cyclopropylbenzamide

2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-{4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-methylurea

1-[4-(7,8-dimethyl-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

1-[4-(4-{[3-(1H-imidazol-1-yl)propyl]amino}-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{7-cyano-4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-{4-[(3-amino-3-oxopropyl)amino]-7-cyanoimidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

1-(4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

4-[4-(butylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{8-fluoro-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{8-fluoro-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{8-fluoro-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(3-amino-3-oxopropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-[7,8-difluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-[4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

1-(4-{7,8-difluoro-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(3-amino-3-oxopropyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl}-2-chloro-N-cyclopropylbenzamide

N-cyclopropyl-4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N<sup>3</sup>-(7,8-dimethyl-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)-beta-alaninamide

1-[4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-N-cyclopropyl-4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7,8-dimethylimidazo[1,2-a]quinoxalin-4-yl}amino)propyl]carbamate

4-{7-cyano-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-{7-cyano-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

1-(4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-4-{7-cyano-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

1-(4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-[4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

1-(4-{4-[(cyclopropylmethyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-(4-{4-[(3-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{4-[(2-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-[(7,8-dimethyl-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)amino]ethanesulfonamide

2-chloro-N-cyclopropyl-4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

2-chloro-N-cyclopropyl-4-{4-[(3-hydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

4-(4-{[2-(acetylamino)ethyl]amino}-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl)-2-chloro-N-cyclopropylbenzamide

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

4-(7-cyano-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

N-{2-[(7-cyano-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)amino]ethyl}acetamide

2-chloro-4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{8-fluoro-4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{8-fluoro-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{8-fluoro-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-[(8-fluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)amino]ethanesulfonamide

2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-8-fluoroimidazo[1,2-a]quinoxalin-4-yl}amino)propyl]carbamate

N-cyclopropyl-4-{7,8-difluoro-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{4-[(3-amino-3-oxopropyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl}benzamide

1-{4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-methylurea

2-chloro-N-cyclopropyl-4-[7,8-difluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(3-methoxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-(4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-[4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-N-cyclopropyl-4-{4-[(2-methoxyethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-{7-cyano-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

1-(4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-4-(7-cyano-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

N-cyclopropyl-4-(8-fluoro-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

1-[4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

N-{2-[(8-fluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin-4-yl)amino]ethyl}acetamide

1-(4-{8-fluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-difluoro-4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide

N-cyclopropyl-4-{7,8-dimethyl-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{4-[(3-hydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

1-(4-{4-[(4-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{7,8-dimethyl-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

2-chloro-N-cyclopropyl-4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]benzamide

2-chloro-N-cyclopropyl-4-{4-[(3-methoxypropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl}benzamide

2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide

4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-{7-cyano-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

4-(7-cyano-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide

4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

1-(4-{7-cyano-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-(4-{7-cyano-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-[4-(7-cyano-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

1-(4-{7-cyano-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)-3-methylurea

1-[4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quinoxalin-1-yl)phenyl]-3-methylurea

2-chloro-4-[7-cyano-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide

4-[4-(benzylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclopropylbenzamide

2-chloro-4-{7-cyano-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbenzamide

and

4-{4-[(3-amino-3-oxopropyl)amino]-7-cyanoimidazo[1,2-a]quinoxalin-1-yl}-2-chloro-N-cyclopropylbenzamide.

5. A method of preparing a compound according to claim 1 , in which method an intermediate compound of general formula (4):

wherein R 1 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined in claim 1 , and Y represents a halogen atom, is allowed to react with an intermediate compound of general formula:

R 2 —Z

in which R 2 is as defined in claim 1 , and Z is a suitable functional group via which the R 2 of the R 2 —Z compound can be coupled onto the Y-bearing carbon atom of a compound (4), thereby replacing said Y with said R 2 moiety,

thus providing a compound of general formula (I):

in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in claim 1 .

6. A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable diluent or carrier.

7. A pharmaceutical combination comprising:

one or more compounds according to claim 1 ;

and

one or more agents selected from: a taxane; an epothilone; Mitoxantrone; Prednisolone; Dexamethasone; Estramustine; Vinblastine; Vincristine; Doxorubicin; Idarubicin; Daunorubicin; Bleomycin; Etoposide; Cyclophosphamide; Ifosfamide; Procarbazine; Melphalan; 5-Fluorouracil; Capecitabine; Fludarabine; Cytarabine; 2-Chloro-2′-deoxyadenosine; Thioguanine; an anti-androgen; Bortezomib; a platinum derivative; Chlorambucil; Methotrexate; and Rituximab.

8. The pharmaceutical combination according to claim 7 , wherein the taxane is selected from Docetaxel and Paclitaxel.

9. The pharmaceutical combination according to claim 7 , wherein the epothilone is selected from Ixabepilone, Patupilone, and Sagopilone.

10. The pharmaceutical combination according to claim 7 , wherein the anti-androgen is selected from Flutamide, Cyproterone acetate, and Bicalutamide.

11. The pharmaceutical combination according to claim 7 , wherein the platinum derivative is selected from Cisplatin and Carboplatin.

12. The compound according to claim 1 , wherein:

R 2 represents an aryl- or heteroaryl-group; wherein said group is substituted one time with —C(═O)NR 9 R 10 and is optionally substituted with a substituent selected from: halo-, hydroxy-, cyano-, C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkyl-.

13. The compound according to claim 1 , wherein:

R 2 represents an aryl- or heteroaryl-group; wherein said group is substituted one time with —C(═O)NH-cyclopropyl and is optionally substituted with a substituent selected from: halo-, hydroxy-, cyano-, C 1 -C 6 -alkyl-, halo-C 1 -C 6 -alkyl-.

Assignments (2)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2013

From: KOPPITZ, MARCUS, DR.; BADER, BENJAMIN, DR.; BOMER, ULF, DR.; KREFT, BERTOLT, DR.; LIENAU, PHILIP, DR.; MARQUARDT, TOBIAS, DR.; PRECHTL, STEFAN, DR.; SIEMEISTER, GERHARD, DR.; WEGSCHEID-GERLACH, CHRISTOF, DR.

To: BAYER PHARMA AKTIENGESELLSCHAFT

Reel/Frame 029965/0390 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 1, 2013

From: BAYER PHARMA AKTIENGESELLSCHAFT

To: BAYER INTELLECTUAL PROPERTY GMBH

Reel/Frame 029906/0035 →