TRANSGENIC ANIMAL CARRYING AT LEAST TWO TYPES OF FOREIGN FUNCTIONAL RNA
The present invention relates to a transgenic animal which intracellularly expresses at least two types of foreign functional RNA and has resistance to a pathogen such as a virus. In the animal carrying multiple types of foreign functional RNA, the proliferation of a pathogen can be more significantly inhibited compared to an animal carrying one type of foreign functional RNA.
1 . A transgenic animal intracellularly expressing at least two types of foreign functional RNA and having resistance to a pathogen.
2 . The transgenic animal according to claim 1 , wherein the functional RNA is one or more polynucleotides (RNAs) selected from shRNAs, miRNAs, ribozymes, siRNAs and aptamers.
3 . The transgenic animal according to claim 1 , wherein the functional RNA is a RNA having a base sequence having 50% or more sequence identity with a complementary strand of a partial genomic base sequence of the pathogen.
4 . The transgenic animal according to any of claim 1 , wherein the resistance to the pathogen corresponds to inhibition of proliferation of the pathogen to 50% or less.
5 . The transgenic animal according to claim 1 , wherein the pathogen is a virus.
6 . The transgenic animal according to claim 5 , wherein the virus is an influenza virus.
7 . The transgenic animal according to claim 1 , wherein the transgenic animal is a bird.
8 . The transgenic animal according to claim 7 , wherein the bird is a domestic poultry.
9 . The transgenic animal according to claim 8 , wherein the domestic poultry is a chicken.