Solid state rapid thermocycling
View Patent ↗The rapid thermal cycling of a material is targeted. A solid state heat exchanger with a first well and second well is coupled to a power module. A thermoelectric element is coupled to the first well, the second well, and the power module, is configured to transfer thermal energy from the first well to the second well when current from the power module flows through the thermoelectric element in a first direction, and is configured to transfer thermal energy from the second well to the first well when current from the power module flows through the thermoelectric element in a second direction. A controller may be coupled to the thermoelectric elements, and may switch the direction of current flowing through the thermoelectric element in response to a determination by sensors coupled to the wells that the amount of thermal energy in the wells falls below or exceeds a pre-determined threshold.
1. A method for thermally cycling a material, comprising:
receiving a sample in each of a first set of wells and each of a second set of wells, each well in the first set of wells and the second set of wells coupled to a plurality of thermoelectric elements, wherein, for each well in the first set of wells, the well is coupled to a first subset of thermoelectric elements, and wherein each thermoelectric element in the first subset of thermoelectric elements is coupled to a different well in the second set of wells;
retrieving electric current from a power module coupled to the thermoelectric elements;
transferring thermal energy from the first set of wells to the second set of wells by flowing current through the thermoelectric elements in a first direction in a first operating mode; and
transferring thermal energy from the second set of wells to the first set of wells by flowing current through the thermoelectric elements in a second direction in a second operating mode.
2. The method of claim 1 , wherein the thermoelectric elements each comprise a first node and a second node, wherein the first node is configured to transfer thermal energy to and from a first well via heat conduction, and wherein the second node is configured to transfer thermal energy to and from a second well via heat conduction.
3. The method of claim 1 , further comprising:
determining the amount of thermal energy in a first well in the first set of wells using one or more sensors coupled to the first well.
4. The method of claim 3 , further comprising:
switching the direction of the current flowing through a thermoelectric element coupled to the first well from the first direction to the second direction responsive to the determined thermal energy in the first well falling below a first threshold.
5. The method of claim 3 , further comprising:
switching the direction of the current flowing through a thermoelectric element coupled to the first well from the second direction to the first direction responsive to the determined thermal energy in the first well exceeding a second threshold.
6. An apparatus for thermally cycling a material, comprising:
a power module configured to provide electric current;
a first set of wells;
a second set of wells; and
a plurality of thermoelectric elements, each thermoelectric element coupled to a first well in the first set of wells, a second well in the second set of wells and the power module, each thermoelectric element configured to:
transfer thermal energy from the first well to the second well when current flows through the thermoelectric element in a first direction; and
transfer thermal energy from the second well to the first well when current flows through the thermoelectric element in a second direction;
wherein, for each well in the first set of wells, the well is coupled to a first subset of thermoelectric elements, and wherein each thermoelectric element in the first subset of thermoelectric elements is coupled to a different well in the second set of wells.
7. The apparatus of claim 6 , wherein each thermoelectric element comprises a first node and a second node, wherein the first node is configured to transfer thermal energy to and from the first well via heat conduction, and wherein the second node is configured to transfer thermal energy to and from the second well via heat conduction.
8. The apparatus of claim 6 , further comprising a controller coupled to each thermoelectric element and configured to switch the direction of the current flowing through each thermoelectric element.
9. The apparatus of claim 8 , further comprising one or more sensors coupled to the first set of wells, the one or more sensors configured to:
determine the amount of thermal energy in a first well of the first set of wells; and
communicate the determined amount of thermal energy to the controller.
10. The apparatus of claim 9 , wherein the controller is further configured to:
switch the direction of the current flowing through the thermoelectric elements from the first direction to the second direction responsive to the determined thermal energy in the first well falling below a first threshold.
11. The apparatus of claim 9 , wherein the controller is further configured to:
switch the direction of the current flowing through the thermoelectric elements from the second direction to the first direction responsive to the determined thermal energy in the first well exceeding a second threshold.
12. The apparatus of claim 6 , wherein for each well in the second set of wells, the well is coupled to a second subset of thermoelectric elements, and wherein each thermoelectric element in the second subset of thermoelectric elements is coupled to a different well in the first set of wells.
13. The apparatus of claim 6 , wherein the first set of wells and the second set of wells are configured to receive a sample tray, the sample tray comprising one or more wells, and wherein the sample tray wells are inserted into the first set of wells and the second set of wells when the sample tray is placed upon the first set of wells and the second set of wells.