PHARMACEUTICALLY ACTIVE COMPOUNDS, THEIR MANUFACTURE, COMPOSITIONS CONTAINING THEM, AND THEIR USE
A substance for use as a medicament, comprises a solid mixed metal compound of formula (I): M II 1-a M III a O b A n− c .zH 2 O (I) where M II is at least one bivalent metal: M III bis at least one trivalent metal; A n− is at least one n-valent anion; 2+a=2b+Σcn; and Σcn<0.9a. The substance may be made by heating at a temperature of from 200° C. to 600° C., preferably from 250° C. to 500° C. of a substance comprising a compound of formula (II): M II 1-x M III x (OH) 2 A n− y .mH 2 O (II) where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; x=Σyn 0<x≦0.5, 0<y≦1 and 0<m≦10.
1 . A substance for use as a medicament, comprising a solid mixed metal compound of formula (I):
M II 1-A M III a O b A n− c .z H 2 O (I)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; 2+a=2b+Σcn and Σcn<0.9a.
2 . A substance according to claim 1 , wherein in formula (I), a is >0.3.
3 . A substance according to claim 1 , wherein in formula (I), a is <0.3.
4 . A substance according to claim 2 , wherein in formula (I), 0.03a<Σcn<0.5a.
5 . A substance according to claim 3 , wherein in formula (I), 0.03a<Σcn<0.7a.
6 . A solid mixed metal compound according to claim 1 , having less than 2%, preferably less than 1.5%, more preferably less than 1% by weight crystallite-surface absorbed water.
7 . A substance for use as a medicament, comprising a solid mixed metal compound obtained or obtainable by heating a starting material comprising a layered double hydroxide structure at a temperature of from 200° C. to 600° C., preferably from 250° C. to 500° C.
8 . A substance according to claim 7 , wherein the starting material comprises a compound of formula (II):
M II 1-x M III x (OH) 2 A n− y .m H 2 O (II)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; x=Σyn, 0<x<=0.5, 0<y<=1 and 0<m≦10.
9 . A substance according to claim 8 , wherein in formula (II), x is >0.3.
10 . A substance according to claim 8 , wherein in formula (II), x is <0.3.
11 . A substance according to claim 7 , wherein the substance has a 10% higher phosphate binding capacity relative to the compound of formula (II) from which it is obtainable.
12 . Use in a method of preparing a medicament for binding of phosphate in an animal in need thereof, of a substance comprising a solid mixed metal compound of formula (I):
M II 1-A M III a O b A n− c .z H 2 O (I)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; 2+a=2b+Σcn and Σcn<0.9a.
13 . Use in a method of preparing a medicament for prophylaxis or treatment of hyperphosphataemia, of a substance comprising a solid mixed metal compound of formula (I):
M II 1-A M III a O b A n− c .z H 2 O (I)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; 2+a=2b+Σcn and Σcn<0.9a.
14 . Use, according to claim 12 , wherein in formula (I), a is >0.3 and preferably 0.03a<Σcn<0.5a.
15 . Use according to claim 12 , wherein in formula (I), a is <0.3 and preferably 0.03a<Σcn<0.7a.
16 . Use in a method of preparing a medicament, for binding of phosphate in an animal in need thereof, of a substance obtainable by heating a starting material comprising a layered double hydroxide structure at a temperature of from 200° C. to 600° C., preferably from 250° C. to 500° C.
17 . Use in a method of preparing a medicament, for prophylaxis or treatment of hyperphosphataemia, of a substance obtainable by heating a starting material comprising a layered double hydroxide structure at a temperature of from 200° C. to 600° C., preferably from 250° C. to 500° C.
18 . Use according to claim 16 , wherein the starting material comprises a compound of formula (II):
M II 1-x M III x (OH) 2 A n− y .m H 2 O (II)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; x=Σny; and 0<x<0.5; 0≦m≦10.
19 . Use, according to claim 18 , wherein in formula (II), x is ≧0.3.
20 . Use according to claim 18 , wherein in formula (II), x is <0.3.
21 . A method of preparing a substance for use as a medicament, the method comprising heating a starting material comprising a layered double hydroxide structure at a temperature of from 200° C. to 600° C., preferably from 250° C. to 500° C.
22 . A method according to claim 21 , wherein the starting material comprises a compound of formula (II):
M II 1-x M III x (OH) 2 A n− y .m H 2 O (II)
where M II is at least one bivalent metal; M III is at least one trivalent metal; A n− is at least one n-valent anion; x=Σny; and 0<x≦0.5, 0≦m≦10.
23 . A method according to claim 22 , wherein in formula (II), x is ≧0.3.
24 . A method according to claim 22 , wherein in formula (II), x is <0.3.
25 . A method according to claim 21 , wherein the starting material is substantially free of particles greater than 100 μm.
26 - 33 . (canceled)