IP Library › Granted Patent US 9,717,694
Granted Patent B2
US 9,717,694 · App. 13/272,042 · Granted Aug 1, 2017

Peptide/particle delivery systems

Inventors: Jordan Jamieson Green (Nottingham, MD); Aleksander S. Popel (Lutherville, MD); Joel Chaim Sunshine (Pikesville, MD); Ron B. Shmueli (Baltimore, MD); Stephany Yi Tzeng (Baltimore, MD); Kristen Lynn Kozielski (Baltimore, MD)
Assignee: THE JOHNS HOPKINS UNIVERSITY
A61K9/5026A61K9/0019A61K9/06A61K9/19A61K9/5146A61K31/711A61K31/713A61K31/7105A61K38/39A61K47/34B82Y5/00C12N15/111C12N15/88C12N2310/14C12N2320/32Y10T428/2982
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Quick Facts
Patent No.
US 9,717,694
App. No.
13/272,042
Granted
Aug 1, 2017
Kind
B2
Abstract

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

Claims (10)

1. A microparticle comprising:

wherein:

n is an integer from 1 to 10,000;

R 1 is absent;

R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each H;

R is selected from the group consisting of:

R′ is selected from the group consisting of:

R″ is selected from the group consisting of:

and poly(lactide-co-glycolide) (PLGA); wherein the microparticle comprises an isolated peptide consisting of EIELVEEEPPF (SEQ ID NO: 2485).

2. The microparticle of claim 1 , comprising a compound having the following structure:

Assignments (2)
CONFIRMATORY LICENSE Recorded May 11, 2020
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 052625/0033 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2011
From: GREEN, JORDAN JAMIESON; POPEL, ALEKSANDER S.; SUNSHINE, JOEL CHAIM; SHMUELI, RON B.; TZENG, STEPHANY YI; ZOZIELSKI, KRISTEN LYNN
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 027366/0029 →
Continuity (7)
Continuation In Part PCTUS2010035127 · May 17, 2010
Provisional Application 61392224 · Oct 12, 2010
Provisional Application 61542995 · Oct 4, 2011
Provisional Application 61543046 · Oct 4, 2011
Provisional Application 61178611 · May 15, 2009
Related Publication 20120114759A1 · May 10, 2012
Related Publication 20160374949A9 · Dec 29, 2016