Predisposition prediction using attribute combinations
A method and system are presented in which predisposition predictions are generated for an individual with respect to an attribute indicated in a query. The predictions are based on the identification of predisposing attribute combinations within the attribute profile of the individual and statistical results that indicate the strength of association of the identified attribute combinations with the query attribute.
1. A computer based method for predisposition prediction wherein a relative likelihood of medical disease predisposition for an individual may be determined based on datasets containing predetermined association of attributes combining pangenetic and non-pangenetic attributes and combinations thereof with said disease, said method performed on a computer including a user interface, a processor, a memory, and a display, comprising:
a) said computer receiving a medical disease associated query attribute via said user interface into said processor;
b) said processor accessing an attribute profile of said individual contained in said memory;
c) said processor accessing a stored dataset in said memory containing said predetermined attribute combinations combining pangenetic and non-pangenetic attributes and statistical results that indicate the strength of association of each of the attribute combinations in said stored dataset, said statistical association having been created by comparing previously submitted and assessed attribute profiles of individuals with the medical disease query attribute and comparing the submitted attribute profiles with attributes profiles of those not having the medical disease query, so as to minimize the impact of shared attribute combinations;
d) identifying attribute combinations from the stored dataset of predetermined attribute combinations associated with said medical disease that occur in the attribute profile of said individual by comparing the attribute combinations occurring in both the attribute profile of the individual and in the dataset attribute profiles; and
e) generating a dataset ranked output of one or more predisposition predictions for the individual based on the identified attribute combinations appearing in both the predetermined dataset and in the attribute profile of said individual and the statistical results indicating a relative predisposition of said individual to acquire said disease.
2. The computer based method of claim 1 , wherein the predisposition predictions are generated based on the statistical results for the largest identified attribute combination.
3. The computer based method of claim 1 , further comprising:
f) storing the predisposition predictions in said memory.
4. The computer based method of claim 1 , further comprising:
f) associating the predisposition predictions with the individual and storing the association in said memory.
5. The computer based method of claim 4 , wherein storing the association comprises storing a link to one or more of an identifier of the individual, the attribute profile of the individual, and a record of the individual.
6. The computer based method of claim 1 , further comprising:
f) repeating steps (a)-(e) for a succession of query attributes to create a tabulated predisposition prediction report, profile or record.
7. The computer based method of claim 1 , further comprising:
f) transmitting the predisposition predictions as output.
8. The computer based method of claim 1 , further comprising:
f) transmitting the predisposition predictions to create an attribute prediction report, profile or record.
9. The computer based method of claim 1 , further comprising:
f) updating attribute combinations and statistical results contained in the dataset based on the content of the attribute profile.
10. The computer based method of claim 1 , wherein the query attribute comprises a combination of two or more attributes.
11. The computer based method of claim 4 , wherein the predisposition predictions meet one or more statistical requirements.
12. The computer based method of claim 8 , wherein the predisposition predictions meet one or more statistical requirements.
13. The computer based method of claim 12 , wherein the one or more statistical requirements are selected from the group consisting of a minimum statistical value, a maximum statistical value, and a value of statistical significance.
14. The computer based method of claim 1 , further comprising:
f) eliminating predisposition predictions that are based on attribute combinations which lack one or more specified attributes.
15. The computer based method of claim 1 , further comprising:
f) eliminating predisposition predictions that are based on attribute combinations which contain one or more specified attributes.
16. A computer based system for predisposition prediction wherein a relative likelihood of medical disease predisposition for an individual may be determined based on datasets containing predetermined association of attributes combining pangenetic and non-pangenetic attributes and combinations thereof with said disease, comprising:
a) a data receiving subsystem processor for receiving a query attribute associated with said medical disease;
b) a first data accessing subsystem memory for accessing a previously stored attribute profile of said individual;
c) a second data accessing subsystem memory for accessing a dataset containing previously stored attribute combinations combining pangenetic and non-pangenetic attributes and statistical results that indicate the strength of association of each of the attribute combinations in said stored dataset with the medical disease query attribute, said statistical strength of association having been created by comparing previously submitted and assessed attribute profiles of individuals with the medical disease query attribute and comparing the submitted attribute profiles with attributes profiles of those not having the medical disease query, so as to minimize the impact of shared attribute combinations;
d) a data processing subsystem processor comprising:
i) a data comparison subsystem means for identifying attribute combinations from the stored data set that occur in the attribute profile of said individual; and
ii) a statistical predisposition prediction subsystem means for generating and displaying one or more predisposition predictions for the individual based on the identified attribute combinations and the statistical results indicating a relative predisposition of said individual to acquire said disease, said prediction of relative predisposition obtained by comparing the attribute combinations occurring in both the attribute profile of the individual and in the respective dataset of attribute profiles.
17. The computer based system of claim 16 , further comprising:
e) a data storage subsystem means for storing the predisposition predictions and for storing an association between the predisposition predictions and the individual.
18. The computer based system of claim 16 , further comprising:
e) a communications subsystem means for transmitting the predisposition predictions.
19. The computer based system of claim 16 , wherein the data processing subsystem further comprises:
iii) a database updating subsystem means for updating attribute combinations and statistical results contained in the set based on the content of the attribute profile.
20. The computer based system of claim 16 , wherein the data processing subsystem further comprises:
iii) a data elimination subsystem means for eliminating predisposition predictions that are based on attribute combinations which lack one or more specified attributes, or alternatively, which contain one or more specified attributes.
21. A computer based system for predisposition prediction wherein a relative likelihood of medical disease predisposition for an individual may be determined based on datasets containing predetermined association of attributes combining pangenetic and non-pangenetic attributes and combinations thereof with the disease, the computer based system comprising:
a) a data receiving subsystem for receiving a query attribute associated with said medical disease;
b) a first data accessing subsystem for accessing a first computer memory containing a previously stored attribute profile of the individual;
c) a second data accessing subsystem for accessing a second computer memory containing a dataset having previously stored attribute combinations combining pangenetic and non-pangenetic attributes and statistical results that indicate the strength of association of each of the attribute combinations in said stored dataset with the medical disease query attribute, said statistical strength of association having been created by comparing previously submitted and assessed attribute profiles of individuals with the medical disease query attribute and comparing the submitted attribute profiles with attributes profiles of those not having the medical disease query, so as to eliminate the impact of shared attribute combinations;
d) a data processor and an associated memory, wherein the associated memory contains machine readable instructions which upon execution by the data processor, execute the method of:
i) identifying attribute combinations from the stored data set that occur in the attribute profile of said individual; and
ii) generating and transmitting for display one or more predisposition predictions for the individual based on the identified attribute combinations and the statistical results indicating a relative predisposition of said individual to acquire the disease, the prediction of relative predisposition obtained by comparing the attribute combinations occurring in both the attribute profile of the individual and in the respective dataset of attribute profiles.