IP Library › Patent Application 13275498
Patent Application
App. No. 13/275,498

Composition For Transdermal Delivery Of Fentanyl

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
13/275,498
Abstract

A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.

Claims (20)

1 . A transdermal drug delivery composition consisting of:

(a) a copolymer comprising the reaction product of:

(i) one or more A monomers selected from the group consisting of alkyl acrylates containing 4 to 12 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to 12 carbon atoms in the alkyl group; and

(ii) one or more ethylenically unsaturated B monomers copolymerizable with the A monomer;

(b) about 8% to about 30% by weight fentanyl based on the total weight of the composition; and, optionally,

(c) a component selected from the group consisting of delivery enhancing adjuvants, tackifiers, plasticizers, and combinations thereof,

wherein the composition is free of undissolved fentanyl.

2 . The composition of claim 1 wherein the A monomer is selected from the group consisting of isooctyl acrylate, 2-ethylhexyl acrylate, butyl acrylate, cyclohexyl acrylate, and combinations thereof.

3 . The composition of claim 1 wherein the A monomer includes isooctyl acrylate.

4 . The composition of claim 1 wherein the B monomer is selected from the group consisting of 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, glyceryl acrylate, N,N-diethylacrylamide, 2-ethoxyethoxyethyl acrylate, 2-ethoxyethyl acrylate, tetrahydrofurfuryl acrylate, acrylic acid, acrylamide, vinyl acetate, N-vinyl pyrrolidone, and combinations thereof.

5 . The composition of claim 1 wherein the B monomer includes 2-hydroxyethyl acrylate.

6 . The composition of claim 1 wherein the copolymer comprises the reaction product of:

(i) one or more A monomers selected from the group consisting of alkyl acrylates containing 4 to 12 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to 12 carbon atoms in the alkyl group;

(ii) one or more ethylenically unsaturated B monomers copolymerizable with the A monomer; and

(iii) a macromonomer.

7 . The composition of claim 1 wherein the concentration of fentanyl in the composition is about 8% by weight.

8 . A device for the transdermal delivery of fentanyl comprising a backing and a composition according to claim 1 , said composition being adhered to one surface of the backing.

9 . A method of providing analgesia to a mammal comprising:

(a) placing the composition of claim 1 on the skin of a mammal; and

(b) allowing the composition to remain on the skin for a time sufficient to establish or maintain an analgesically effective blood level of fentanyl in the mammal.