IP Library Granted Patent US 8,835,394
Granted Patent B2
US 8,835,394 · App. 13/276,068 · Granted Sep 16, 2014

Treatment for basal cell carcinoma

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Quick Facts
Patent No.
US 8,835,394
App. No.
13/276,068
Granted
Sep 16, 2014
Kind
B2
Abstract

The present invention provides a method of treating basal cell carcinoma in a subject. Generally, the method includes administering to the subject an amount of IRM compound effective for treating basal cell carcinoma in a treatment cycle that includes at least two consecutive days in which the IRM compound is administered and at least one day in which the IRM compound is not administered.

Claims (12)

1. A method of treating basal cell carcinoma in a subject, the method consisting essentially of administering to the subject an amount of an Immune Response Modifier (IRM) compound effective for treating basal cell carcinoma, wherein administering the IRM compound comprises topically applying the IRM compound to a treatment area that includes a lesion, and wherein the IRM compound is administered in a treatment cycle that comprises five consecutive days in which the IRM compound is administered and at least two consecutive days in which the IRM compound is not.

2. The method of claim 1 wherein the method comprises at least two treatment cycles.

3. The method of claim 2 wherein the method comprises at least six treatment cycles.

4. The method of claim 1 wherein administering the IRM compound comprises applying one dose of the IRM compound per day.

5. The method of claim 1 wherein the IRM compound is applied in a formulation that comprises from about 1% to about 10% IRM compound.

6. The method of claim 5 wherein the formulation comprises about 5% IRM compound.

7. The method of claim 5 wherein the formulation is applied to the treatment area for from about two hours to about 24 hours.

8. The method of claim 7 wherein the formulation is applied to the treatment area for from about six hours to about twelve hours.

9. The method of claim 5 wherein the formulation is applied to the treatment area for about eight hours.

10. The method of claim 1 wherein the treatment area further comprises skin at least 0.5 cm beyond the margin of the lesion.

11. The method of claim 1 wherein the IRM compound is a 2-aminopyridine fused to a five membered nitrogen-containing heterocyclic ring.

12. The method of claim 1 wherein the IRM compound is imiquimod.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
NOTICE OF SUCCESSION OF AGENCY Recorded Jan 9, 2015
From: GOLDMAN SACHS LENDING PARTNERS, LLC
To: BARCLAYS BANK PLC, AS SUCCESSOR AGENT
Reel/Frame 034749/0689 →
SECURITY AGREEMENT Recorded Apr 24, 2013
From: MEDICIS PHARMACEUTICAL CORPORATION
To: GOLDMAN SACHS LENDING PARTNERS LLC
Reel/Frame 030281/0433 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2011
From: OWENS, MARY L.; FOX, TERRANCE L.; GINKEL, ANGELA M.
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 027093/0928 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2011
From: 3M INNOVATIVE PROPERTIES COMPANY
To: GRACEWAY PHARMACEUTICALS LLC
Reel/Frame 027094/0001 →