Thiazolidinedione analogues for the treatment of metabolic diseases
View Patent ↗The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases.
1. A method of treating diabetes comprising administering to a patient in need thereof a compound selected from
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the diabetes being treated is type-2 diabetes.
3. The method of claim 1 , wherein the diabetes being treated is type-1 diabetes.
4. A method of treating diabetes comprising administering to a patient in need thereof a pharmaceutical composition comprising a compound selected from
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. The method of claim 4 , wherein the pharmaceutical composition further comprises a DPP-4 inhibitor.
6. The method of claim 5 , wherein the DPP-4 inhibitor is selected from sitagliptin, vildagliptin, or any combination thereof.
7. The method of claim 4 , wherein the pharmaceutical composition further comprises a GLP-1 agonist, a GLP-2 agonist, or any combination thereof.
8. The method of claim 4 , wherein the pharmaceutical composition further comprises a statin.
9. The method of claim 8 , wherein the statin is selected from atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, simvastatin, rosuvastatin, pravastatin, or any combination thereof.