Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications
View Patent ↗A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
1. A method of treating Alzheimer's disease comprising administering to a patient in need thereof an effective amount of a phospholipid composition, wherein the phospholipid composition comprises:
a phospholipid of the general formula (I),
wherein R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue, and
wherein X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3 or
wherein the composition is suitable for human consumption.
2. The method of claim 1 , wherein X is
3. A method of treating Alzheimer's disease comprising administering to a patient in need thereof an effective amount of a krill oil extract,
wherein:
the extract comprises a phospholipid of the formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue, and X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3 , or
the extract is extracted under conditions suitable for preserving an intact phospholipid;
the extract comprises phospholipids in an amount of at least 40% w/w;
the extract comprises omega-3 fatty acids in an amount of at least 15% w/w;
the extract comprises astaxanthin; and
the extract is suitable for human consumption.
4. The method of claim 3 , wherein said composition is contained in a tablet or capsule suitable for oral administration.
5. A method of treating Alzheimer's disease comprising administering to a patient in need thereof an effective amount of a phospholipid composition, wherein the phospholipid composition comprises:
a phospholipid of the general formula (I),
wherein R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue, and
wherein X is
wherein the composition is suitable for human consumption.
6. A method of treating Alzheimer's disease comprising administering to a patient in need thereof an effective amount of a krill oil extract,
wherein:
the krill oil extract comprises a phospholipid of the formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue, and X is
the extract is extracted under conditions suitable for preserving an intact phospholipid;
the extract comprises phospholipids in an amount of at least 40% w/w;
the extract comprises omega-3 fatty acids in an amount of at least 15% w/w;
the extract comprises astaxanthin; and
the extract is suitable for human consumption.
7. The method of claim 6 , wherein said composition is contained in a tablet or capsule suitable for oral administration.