Method and/or system for multicompartment analyte monitoring
View Patent ↗Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
1. A method comprising:
using a processor:
modeling a latency in transportation of an analyte between first and second physiological compartments; and
compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment, wherein said one or more measurements are obtained based, at least in part, on one or more values of a sensor signal, and wherein modeling the latency further comprises modeling the latency based, at least in part, on an estimated rate of change in said sensor signal.
2. The method of claim 1 , wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.
3. The method of claim 1 , wherein said one or more values of a sensor signal comprises a measured current responsive to a concentration of said analyte in said second physiological compartment.
4. The method of claim 1 , wherein estimating the concentration of the analyte in the first physiological compartment further comprises:
multiplying the one or more sensor signal value by a first coefficient to provide a first product;
multiplying the estimated rate of change by a second coefficient to provide a second product; and
estimating the concentration of the analyte in the second physiological compartment based, at least in part, on a combination of said first and second products.
5. The method of claim 4 , wherein the first and second coefficients are determined based, at least in part, on an estimate of said latency.
6. The method of claim 4 , wherein the first and second coefficients are selected based, at least in part, so as to provide a lowest error between measurements of said analyte in said second physiological compartment based on sensor measurements and reference samples of said analyte in said first physiological compartment.
7. The method of claim 4 , wherein said coefficients are based, at least in part, on a substantially linear response of said sensor signal to said concentration of analyte in said second physiological compartment.
8. The method of claim 4 , wherein said coefficients are based, at least in part, on a non-linear response of said sensor signal to said concentration of analyte in said second physiological compartment.
9. The method of claim 1 , wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient's interstitial fluid to affect a blood glucose concentration in said patient.
10. The method of claim 9 , wherein the latency is defined based, at least in part, on a time for 63% of glucose in said interstitial fluid to be absorbed by the patient's blood.
11. The method of claim 1 , wherein modeling the latency comprises estimating a plurality of parameters of an estimator of said concentration of the analyte in the first physiological compartment, at least one of said parameters comprising an estimate of said latency.
12. The method of claim 11 , wherein compensating for said latency further comprises:
applying said estimate of said latency to sensor signals generated responsive to said one or more measurements of a concentration of the analyte in the second physiological compartment to provide at least one latency compensated measurement; and
computing an estimate of said concentration of said analyte in said first physiological compartment based, at least in part, on the at least one latency compensated measurement.
13. An apparatus comprising:
a sensor to generate a signal responsive to a concentration of an analyte in a second physiological compartment; and
a processor configured to:
model a latency in transportation of the analyte between the second physiological compartment and a first physiological compartment; and
compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment, wherein said one or more measurements are obtained based, at least in part, on one or more values of the sensor signal, and wherein said processor is further configured to model the latency based, at least in part, on an estimated rate of change in said sensor signal.
14. The apparatus of claim 13 , wherein the one or more values of a sensor signal comprises a measured current responsive to a concentration of said analyte in said second physiological compartment.
15. The apparatus of claim 13 , wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient's interstitial fluid to affect a blood glucose concentration in said patient.
16. The apparatus of claim 15 , wherein the latency is defined based, at least in part, on a time for 63% of glucose in said interstitial fluid to be absorbed by the patient's blood.
17. The apparatus of claim 15 , wherein the processor is further configured to model the latency by estimating a plurality of parameters of an estimator of said concentration of the analyte in the first physiological compartment, at least one of said parameters comprising an estimate of said latency.
18. The apparatus of claim 17 , wherein the processor is further configured to compensate for said latency by:
applying said estimate of said latency to sensor signals generated responsive to said one or more measurements of a concentration of the analyte in the second physiological compartment to provide at least one latency compensated measurement; and
computing an estimate of said concentration of said analyte in said first physiological compartment based, at least in part, on the at least one latency compensated measurement.
19. An apparatus comprising:
means for modeling a latency in transportation of an analyte between first and second physiological compartments based, at least in part, on an estimated rate of change in a sensor signal; and
means for compensating for the latency in estimating a concentration of the analyte in the first physiological compartment, based at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment.
20. An article comprising:
a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to:
model a latency in transportation of an analyte between first and second physiological compartments; and
compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment, wherein said one or more measurements are obtained based, at least in part, on one or more values of a sensor signal, and wherein said instructions are further executable by said special purpose computing apparatus to model the latency based, at least in part, on an estimated rate of change in said sensor signal.
21. The article of claim 20 , wherein said one or more values of a sensor signal comprises a measured current responsive to a concentration of said analyte in said second physiological compartment.