Shelf stable pharmaceutical depot
A pharmaceutical depot includes a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less and at least 25% wt solid particles suspended in the biodegradable polymer. The pharmaceutical depot also includes a post-operative pain relieving therapeutic agent.
1. A pharmaceutical depot comprising:
a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less, the biodegradable polymer comprising poly(D,L-lactide-co-glycolide) thereof;
solid particles of mannitol in an amount of at least 40% by weight suspended in the biodegradable polymer, the solid particles have a particle size in a range from 50 to 100 micrometers and the pharmaceutical depot comprises methoxypoly(ethylene glycol); and
a post-operative pain relieving therapeutic agent in an amount of between 0.01 and 10% by weight.
2. A pharmaceutical depot according to claim 1 , wherein the post-operative pain relieving therapeutic agent is a clonidine.
3. A flowable pharmaceutical depot according to claim 1 , wherein the solid particles further comprise hydrophobic solids.
4. A pharmaceutical depot according to claim 1 , wherein the solid particles comprise hydrophilic solids.
5. A pharmaceutical depot according to claim 1 , wherein the solid particles further comprise hydroxypropylmethyl cellulose.
6. A pharmaceutical depot according to claim 1 , wherein the solid particles have a particle size in a range from 50 to 100 micrometers.
7. A pharmaceutical depot according to claim 1 , wherein the biodegradable polymer having a glass transition temperature in a range from 0 to 15 degrees centigrade.
8. A pharmaceutical depot comprising:
a biodegradable polymer having a glass transition temperature in a range from of 0 to 15 degrees centigrade, the biodegradable polymer comprising poly(D,L-lactide-co-glycolide);
solid particles comprising mannitol in an amount of 25-50% by weight suspended in the biodegradable polymer and the pharmaceutical depot comprises methoxypoly(ethylene glycol); and
a post-operative pain relieving therapeutic agent comprising clonidine in an amount of between 0.01 and 10% by weight.
9. A pharmaceutical depot according to claim 8 , wherein the pharmaceutical depot comprises at least 40% wt solid particles suspended in the biodegradable polymer.
10. A flowable pharmaceutical depot according to claim 8 , wherein the solid particles comprise hydrophobic solids.
11. A pharmaceutical depot according to claim 8 , wherein the solid particles further comprise hydrophilic solids.
12. A pharmaceutical depot according to claim 8 , wherein the solid particles further comprise hydroxypropylmethyl cellulose.
13. A pharmaceutical depot comprising:
a biodegradable polymer having a glass transition temperature in a range from of 0 to 15 degrees centigrade, the biodegradable polymer comprising poly(D,L-lactide-co-glycolide);
solid particles comprising mannitol in an amount of 40-50% by weight suspended in the biodegradable polymer, the solid particles have a particle size in a range from 50 to 100 micrometers and the pharmaceutical depot comprises methoxypoly(ethylene glycol); and
a post-operative pain relieving therapeutic agent comprising clonidine in an amount of between 0.01 and 10% by weight.
14. A pharmaceutical depot according to claim 13 , wherein the solid particles comprise hydroxypropylmethyl cellulose.
15. A pharmaceutical depot according to claim 1 , wherein the pharmaceutical depot is in the form of a flexible film configured to be laid into a surgical site.
16. A pharmaceutical depot according to claim 8 , wherein the pharmaceutical depot is in the form of a flexible film configured to be laid into a surgical site.
17. A pharmaceutical depot according to claim 8 , wherein the mannitol is in the depot in an amount of 50% w/w and the methoxypoly(ethylene glycol) is in the depot in an amount of 10% w/w and the depot releases 100% of the clonidine in one day.
18. A pharmaceutical depot according to claim 8 , wherein the mannitol is in the depot in an amount of 25% w/w and the methoxypoly(ethylene glycol) is in the depot in an amount of 15% w/w and the depot releases 80% of the clonidine in one day.