System and method for spray drying a liquid
View Patent ↗Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
1. A spray drying assembly, comprising:
a spray drying head attachable to a gas supplier and a liquid sample, the spray drying head receiving a flow of aerosolizing gas and adapted to provide an aerosolized flow of liquid sample and receiving a flow of drying gas, the spray drying head exposing the aerosolized flow of liquid sample to the drying gas;
a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder suspended in humid air, the drying chamber defining an elongated central lumen open at one end to receive the aerosolized flow of liquid sample and drying gas and open at an opposite end to discharge dried powder and humid air; and
a collection device comprising:
an inlet port in fluid communication with the opposite end of the drying chamber;
a filter adapted to separate the dried powder from the humid air;
a reservoir sized to accommodate at least the dried powder; and
an exhaust port allowing humid air to exit the collection device.
2. The spray drying assembly of claim 1 , wherein the spray drying head is sealably attached to one of the open ends of the drying chamber.
3. The spray drying assembly of claim 1 , wherein the drying chamber extends along an elongated axis, both ends of the central lumen positioned along the common axis.
4. The spray drying assembly of claim 3 , wherein the drying chamber is formed from a thin-walled, collapsible material.
5. The spray drying assembly of claim 1 , wherein at least a portion of the drying chamber is substantially transparent, allowing observation of an interior region of the chamber.
6. The spray drying assembly of claim 1 , wherein the collection device is sized to accommodate dried powder resulting from processing of a single unit of liquid sample of a volume of no more than about 450 ml (about 0.951 pints).
7. The spray drying assembly of claim 1 , wherein the collection device comprises a collection bag formed from a thin-walled, collapsible material.
8. The spray drying assembly of claim 7 , wherein at least a portion of the collection device is substantially transparent, allowing for observation of an interior region of the collection device.
9. The spray drying assembly of claim 1 , further comprising at least one filter configured to filter bacteria from the flow of aerosolizing gas and the flow of drying gas.