Heteroaryl compounds and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
W is —O—or —NH—;
R 1 is —OR;
each R is independently C 1-4 alkyl or C 1-4 fluoroalkyl;
each of R 2 and R 3 is independently hydrogen, —OH, or —OR; and
R 4 is —CF 3 , Cl, or Br,
wherein the compound is not
2. The compound according to claim 1 , having at least one definition selected from (a), (b), (c), (d), or (e):
(a) W is —O—;
(b) R 1 is —OCH 3 ;
(c) R 2 is hydrogen or —OCH 3 ;
(d) R 3 is hydrogen or —OCH 3 ; or
(e) R 4 is —CF 3 or —Cl.
3. The compound according to claim 2 , having at least two definitions selected from (a), (b), (c), (d), or (e).
4. The compound according to claim 3 , having at least three definitions selected from (a), (b), (c), (d), or (e).
5. The compound according to claim 4 , having at least four definitions selected from (a), (b), (c), (d), or (e).
6. The compound according to claim 1 , having at least one definition selected from (a), (b), (c), (d), or (e):
(a) W is —NH—;
(b) R 1 is —OCH 3 ;
(c) R 2 is hydrogen or —OCH 3 ;
(d) R 3 is hydrogen or —OCH 3 ; or
(e) R 4 is —CF 3 or —Cl.
7. The compound according to claim 6 , having at least two definitions selected from (a), (b), (c), (d), or (e).
8. The compound according to claim 7 , having at least three definitions selected from (a), (b), (c), (d), or (e).
9. The compound according to claim 8 , having at least four definitions selected from (a), (b), (c), (d), or (e).
10. The compound according to claim 1 , having at least one definition selected from (a), (b), (c), (d), or (e):
(a) W is —O—or —NH—;
(b) R 1 is OCH 3 ;
(c) R 2 is hydrogen or —OCH 3 ;
(d) R 3 is hydrogen or OCH 3 ; or
(e) R 5 is —CF 3 or —Cl.
11. The compound according to claim 10 , having at least two definitions selected from (a), (b), (c), (d), or (e).
12. The compound according to claim 11 , having at least three definitions selected from (a), (b), (c), (d), or (e).
13. The compound according to claim 12 , having at least four definitions selected from (a), (b), (c), (d), or (e).
14. The compound according to claim 1 , wherein said compound is selected from:
or a pharmaceutically acceptable salt thereof.
15. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
16. The composition according to claim 15 , in combination with an additional therapeutic agent.
17. The composition according to claim 16 , wherein the additional therapeutic agent is a chemotherapeutic agent.