Synthetic analogs of bacterial quorum sensors
View Patent ↗Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.
1. A method of reducing bacterial pathogenicity comprising:
a) providing a biological system comprising pathogenic bacteria which produce a natural quorum-sensing molecule;
b) providing a synthetic bacterial quorum-sensing molecule having the structure:
c) introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria.
2. The method of claim 1 , wherein the pathogenic bacteria are selected from the group consisting of Pseudomonas aeruginosa, Yersinia pestis, Yersinia enterocolitca, Yersinia pseudotuberculosis, Burkholderia cepecia , and combinations thereof.
3. The method of claim 1 , wherein the pathogenic bacteria is Pseudomonas aeruginosa.
4. A method of reducing bacterial pathogenicity comprising:
a) providing a biological system comprising pathogenic bacteria which produce a natural quorum-sensing molecule;
b) providing a synthetic bacterial quorum-sensing molecule having the structure:
c) introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria.
5. The method of claim 4 , wherein the pathogenic bacteria are selected from the group consisting of Pseudomonas aeruginosa, Yersinia pestis, Yersinia enterocolitca, Yersinia pseudotuberculosis, Burkholderia cepecia , and combinations thereof.
6. The method of claim 5 , wherein the pathogenic bacteria is Pseudomonas aeruginosa.