Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics
View Patent ↗The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
1. A method of treating senile dementia, Parkinson's disease, trisomy 21, Korsakoff's alcoholic syndrome, vascular dementia, cranial trauma or motor disorders observed in Parkinson's disease, comprising administering to a patient in need of said treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:
in which:
R is
either a hydrogen or halogen atom;
or a phenyl group optionally substituted with one or more halogen atoms, or with one or more groups selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, nitro, amino, di(C 1 -C 3 )alkylamino, trifluoromethyl, trifluoromethoxy, cyano, hydroxyl, acetyl or methylenedioxy groups;
or a group selected from pyridinyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, thienyl, furyl, isoxazolyl, isothiazolyl, pyrrolyl and naphthyl, it being possible for this group to be optionally substituted with one or more groups selected from halogen atoms, and (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, hydroxyl, amino, (C 1 -C 6 )alkylamino or di(C 1 -C 6 )alkylamino groups.
2. The method according to claim 1 , wherein in the compound:
R is
either a halogen atom,
or a phenyl group optionally substituted with one or more halogen atoms, or with one or more groups selected from (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy groups;
or a group selected from pyridinyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, thienyl, furyl, isoxazolyl, isothiazolyl, pyrrolyl and naphthyl, it being possible for this group to be optionally substituted with one or more (C 1 -C 6 )alkyl groups.
3. The method according to claim 2 , for the treatment of Parkinson's disease.
4. The method according to claim 1 , wherein in the compound:
R is
either a halogen atom;
or a phenyl group optionally substituted with one or more halogen atoms, or with one or more groups selected from (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy groups;
or a group selected from pyridinyl, pyrazolyl, imidazolyl, thienyl, furyl and pyrrolyl, it being possible for this group to be optionally substituted with one or more (C 1 -C 6 )alkyl groups.
5. The method according to claim 4 , for the treatment of Parkinson's disease.
6. The method according to claim 1 , for the treatment of Parkinson's disease.