Method of performing hemofiltration
View Patent ↗A multi-part substitution infusion fluid for an extracorporeal blood treatment and methods for using same are provided. Generally, the multi-part substitution fluid comprises a first solution composed of electrolytes but without divalent cations and a second solution comprising divalent cations. Another embodiment includes a third solution comprising a matching citrate/citric acid anticoagulant. The described methods of using the multi-part substitution infusion fluids significantly reduce risks associated with various extracorporeal blood treatments.
1. A method of performing hemofiltration, the method comprising:
extracting blood from a patient;
passing the blood through an artificial kidney having a semi-permeable membrane, wherein the blood is filtered over a semi-permeable membrane;
infusing a sterile, two part aqueous substitution infusion fluid into the filtered blood, wherein the sterile, two part aqueous substitution infusion fluid comprises a first aqueous substitution infusion fluid comprising sodium ions, potassium ions and phosphate ions and excluding calcium ions and magnesium ions, and a second aqueous substitution infusion fluid comprising calcium ions and magnesium ions; and
returning the infused blood to the patient.
2. The method of claim 1 , wherein the first aqueous substitution infusion fluid and the second aqueous substitution infusion fluid comprise sodium ions.
3. The method of claim 1 , wherein the second aqueous substitution infusion fluid comprises from about 70 mmol/L to about 130 mmol/L of sodium ion.
4. The method of claim 1 , wherein the second aqueous substitution infusion fluid comprises from about 0.01 mmol/L to about 5 mmol/L of potassium ion.
5. The method of claim 1 , wherein the second aqueous substitution infusion fluid comprises from about 100 mmol/L to about 150 mmol/L of chloride ion.
6. The method of claim 1 , wherein the first aqueous substitution infusion fluid comprises from about 0.01 mmol/L to about 1.5 mmol/L of the phosphate ion.
7. The method of claim 1 , wherein the second aqueous substitution infusion fluid comprises from about 2 mmo/n to about 11.5 mmol/L of glucose.
8. The method of claim 1 , wherein the first aqueous substitution infusion fluid comprises from about 0.01 mmol/L of potassium ion to about 5 mmol/L of potassium ion, from about 100 mmol/L to about 150 mmol/L of chloride ion, and from about 0.01 mmol/L to about 1.5 mmol/L of phosphate ion, and wherein the second aqueous substitution infusion fluid comprises from about 10 mmol/L to about 35 mmol/L of calcium ion and from about 2.5 mmol/L to about 20 mmol/L of magnesium ion.
9. The method of claim 1 , wherein a mixed first aqueous substitution infusion fluid and second aqueous substitution infusion fluid excludes acetate.