Steroids as agonists for FXR
View Patent ↗The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
1. A method for the treatment of cholestatic liver disease, atherosclerosis, arteriosclerosis, hypercholesteremia, or hyperlipidemia comprising administering a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I)
or a pharmaceutically acceptable salt or amino acid conjugates thereof, wherein R is ethyl and at least one pharmaceutical carrier or diluent, wherein said compound is administered at 0.01 mg/kg to 100 mg/kg per dose.
2. The method of claim 1 , wherein the composition is administered orally.
3. The method of claim 1 , wherein the composition is administered as a single daily dose.
4. The method of claim 1 , wherein the administration is the compound of formula I