IP Library › Patent Application 13291514
Patent Application
App. No. 13/291,514

NON-SEDATING ANTIHISTAMINE INJECTION FORMULATIONS AND METHODS OF USE THEREOF

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Patent No.
US None
App. No.
13/291,514
Abstract

Described herein are automatic injectors suitable for administration of a non-sedating antihistamine, and methods of using the automatic injectors. A specific non-sedating antihistamine is cetirizine. The automatic injectors are useful in treating acute urticaria or angioedema associated with an acute allergic reaction including anaphylaxis.

Claims (13)

1 . A method of treating acute urticaria or angioedema associated with an acute allergic reaction including anaphylaxis in an individual in need thereof, comprising

self-administering from an automatic injector a pre-measured dose of a non-sedating antihistamine composition subcutaneously or intramuscularly,

wherein the non-sedating antihistamine composition comprises a non-sedating antihistamine and a pH adjusting agent and has a pH of 3 to 9, wherein the non-sedating antihistamine comprises cetirizine or a salt thereof,

wherein the automatic injector comprises a housing comprising a chamber for the non-sedating antihistamine composition and a dispensing assembly in communication with the chamber.

2 . The method of claim 1 , wherein the non-sedating antihistamine composition further comprises ranitidine, cimetidine, epinephrine, methylprednisolone, prednisolone, or a combination thereof.

3 . The method of claim 1 , further comprising self-administering from a second automatic injector an epinephrine composition, wherein the second automatic injector comprises a second housing comprising a second chamber for the epinephrine composition and a second dispensing assembly in communication with the second chamber.

4 . The method of claim 1 , wherein treating is in an emergency situation.

5 . The method of claim 1 , wherein self-administering the non-sedating antihistamine from the automatic injector is non-cardiotoxic and non-sedating.

6 . An automatic injector for self-administration of a pre-measured dose of a non-sedating antihistamine composition subcutaneously or intramuscularly, comprising

a housing comprising a chamber for the non-sedating antihistamine composition and a dispensing assembly in communication with the chamber,

wherein the non-sedating antihistamine composition comprises a non-sedating antihistamine and a pH adjusting agent and has a pH of 3 to 9, wherein the non-sedating antihistamine comprises cetirizine or a salt thereof.

7 . The automatic injector of claim 6 , wherein the non-sedating antihistamine composition further comprises ranitidine, cimetidine, epinephrine, methylprednisolone, prednisolone, or a combination thereof.

8 . A kit comprising the automatic injector comprising a non-sedating antihistamine composition of claim 6 , and a second automatic injector comprising a second housing comprising a second chamber for an epinephrine composition and a second dispensing assembly in communication with the second chamber.