Adhesive compounds and methods use for hernia repair

1. A method of hernia repair, comprising

a) providing a subject having a hernia;

b) providing a construct comprising an adhesive compound and a support wherein said adhesive compound is a multi-hydroxyl phenyl derivative polymer, a multi-methoxy phenyl derivative polymer, a combination multi-hydroxyl and multi-methoxy phenyl derivative polymer, a mono-methoxy and mono-hydroxyl phenyl derivative polymer or a combination thereof wherein said adhesive compound is p(CL1.25kEG10kb-g-DH2), p(CL2kGEG10kb-g-DMu2), p(CL1.25kEG10kb-g-DMu2), p(CL5.6kEG10kb-g-DH2), p(LA4.2kEG10kb-g-DH2), p(CL2kEG10k(SA)b-g-DMe2, p(CL1.25kEG10k(SA)b-g-DMe2), p(CL2kEG10kb-g-MTu2), p(CL2kEG10kb-g-DMPAu2), p(CL2kEG10k(GA)b-g-DMe2), p(CL2kEG10k(GABA)b-g-DHe2), p(CL2kEG10k(GABA)b-g-HFe2), p(CL2kEG10k(GABA)b-g-DMHCAe2), p(CL2kEG10k(GA)b-g-MTe2) or a combination thereof, and

c) affixing said construct to said subject to repair said hernia.

2. The method of claim 1 , wherein said hernia is a congenital hernia, an acquired hernia, an inguinal hernia, an indirect inguinal hernia, a direct inguinal hernia, a saddle bag hernia, a sliding hernia, an umbilical hernia, a paraumbilical hernia, an incisional hernia, a ventral hernia, a femoral hernia, a Copper's hernia, an epigastric hernia, a Spigelian hernia, a semilunar hernia, a Littre's hernia, a Richter's hernia, a lumbar hernia, a sciatic hernia, a sports hernia, an Amyand's hernia, an anal hernia, a Maydl hernia, a hiatus hernia, a diaphragmatic hernia, a paraesophageal hernia, a perineal hernia, a properitoneal hernia, a mesenteric hernia, an intraparietal hernia, a bilateral hernia, a complicated hernia, an incarcerated hernia, a strangulated hernia, an uncomplicated hernia, a complete hernia, an incomplete hernia, an intracranial hernia, an internal hernia, an external hernia or a combination thereof.

3. The method of claim 1 , wherein said subject is a mammal.

4. The method of claim 3 , wherein said mammal is a human.

5. The method of claim 1 , wherein said adhesive compound is a liquid, a coating or a film.

6. The method of claim 1 , wherein said polymer is polyethylene glycol (PEG) polymer, a polycaprolactone (PCL) polymer, a polylactic acid (PLA) polymer, a polyester polymer, a multiblock polymer or combination thereof.

7. The method of claim 1 , wherein said adhesive compound is configured to degrade at a predetermined rate.

8. The method of claim 1 , wherein said adhesive compound is activated in situ.

9. The method of claim 8 , wherein said activated adhesive compound is activated by water, by saline, by at least one bodily fluid, by temperature, by pH, or by pressure.

10. The method of claim 1 , wherein said adhesive compound comprises an oxidant.

11. The method of claim 10 , wherein said oxidant is embedded within said adhesive compound.

12. The method of claim 10 , wherein said oxidant is applied to said adhesive compound by spraying, brushing or dipping or a combination thereof.

13. The method of claim 1 , wherein said support is an adhesive compound polymer, a film polymer, a scaffold, a membrane, a graft, an implant, a mesh or a combination thereof.

14. The method of claim 13 , wherein said support is a synthetic support or a biologic support.

15. The method of claim 14 , wherein said synthetic support comprises a polypropylene support, a polyester support, a condensed polytetrafluoroethylene (cPTFE) support, an expanded polytetrafluoroethylene (cPTFE) support, a polycarbonate polyurethane-urea support, a copolymer of polyglycolide, polyactide and polytrimethylene support, a copolymer polyactide support, a polytrimethylene carbonate support, a polylactic acid (PLA) support, a tyrosine polyarylate support, a polydroxyalkanoate support, a silk-elastin polymer support or a combination thereof.

16. The method or claim 14 , wherein said biologic support comprises a dermis support, a human-derived dermis support, a porcine-derived dermis support, a bovine-derived dermis support, a collagen-containing matrix support, an engineered dermis support, a pericardium support, an extracellular matrix support, or a small intestine submucosa support.

17. The method of claim 1 , wherein said adhesive compound is coated upon said support in a predetermined pattern.

18. The method of claim 17 , wherein said pattern comprises at least one region coated with said adhesive compound and at least one region not coated with said adhesive compound.

19. The method of claim 1 , wherein said affixing comprises a tissue adhesive, a suture, a staple, a tack or a combination thereof.

20. The method of claim 1 , wherein said construct comprises an adhesive compound on at least one surface of said support, and a non-adhesive compound on at least one surface of said support.

21. The method of claim 20 , wherein said non-adhesive compound comprises an anti-adhesive compound.

22. The method of claim 20 , wherein said non-adhesive compound comprises an oxidant.