Medical Devices Containing Nitroprusside and Antimicrobial Agents
A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon, The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device, a base material is impregnated with sodium nitroprusside, the medical device is formed from the base material, and the medical device is coated with an antimicrobial agent.
1 . A method of fabricating a medical catheter, the method comprising:
impregnating a base material with nitroprusside;
forming the medical catheter from the base material; and
coating the medical catheter with an antimicrobial agent
2 . The method according to claim 1 , further comprising:
impregnating the base material with sodium nitroprusside;
3 . The method according to claim 1 , further comprising:
coating the medical catheter with silver.
4 . The method according to claim 3 , further comprising:
coating the medical catheter with nano-scale particles of silver.
5 . The method according to claim 1 , further comprising:
coating the medical catheter with chlorhexidine base and/or a pharmaceutically acceptable salt thereof.
6 . The method according to claim 5 , further comprising:
coating the medical catheter with chlorhexidine diacetate.
7 . The method according to claim 5 , further comprising:
coating the medical catheter with chlorhexidine dodecanoate.
8 . The method according to claim 5 , further comprising:
coating the medical catheter with chlorhexidine palmitate.
9 . The method according to claim 1 , further comprising:
impregnating the base material with an antimicrobial dye.
10 . The method according to claim 9 , wherein the antimicrobial dye includes one or more of gentian violet, methyl violet, brilliant green, and methylene blue.
11 . The method according to claim 1 , further including:
coating the medical catheter with an antibiotic agent.
12 . The method according to claim 11 , wherein the antibiotic agent includes rifampin.
13 . The method according to claim 1 , further comprising:
forming a tubular structure from the base material.
14 . The method according to claim 1 , wherein the base material is a polymer.
15 . The method according to claim 14 , wherein the base material is a polyurethane.
16 . A method of fabricating a medical catheter, the method comprising:
mixing a base material with nitroprusside and an antimicrobial agent; and
melt processing and extruding the mixture to fabricate the medical catheter.
17 . The method according to claim 16 , further comprising:
mixing the base material with silver.
18 . The method according to claim 17 , further comprising:
mixing the base material with nano-scale particles of silver.
19 . The method according to claim 1 , further comprising:
mixing the base material with chlorhexidine base and/or a pharmaceutically acceptable salt thereof and an antimicrobial dye including one or more of gentian violet, methyl violet, brilliant green, and methylene blue.
20 . The method according to claim 19 , further comprising:
mixing the base material with chlorhexidine dipalmitate and gentian violet.