Granted Patent B2

US 10,478,168 · App. 13/294,222 · Granted Nov 19, 2019

Abstract

Claims (31)

1. A device for treating an incision, hernia, or abdominal wall defect, comprising:

an elongate element having a first longitudinal axis; and

at least one sheet connected to the elongate element along the first longitudinal axis;

wherein the at least one sheet comprises an acellular dermal tissue matrix derived from porcine dermis having a Young's modulus within a range of 49.5 MPa to 94.7 MPa.

2. The device of claim 1 , wherein the at least one sheet is connected to the elongate element along an approximate midline of the sheet.

3. The device of claim 1 , wherein the tissue is from an α1,3-galactosyltransferase (α1,3GT) deficient pig.

4. The device of claim 1 , wherein the elongate element comprises an acellular dermal tissue matrix.

5. The device of claim 4 , wherein the elongate element comprising the acellular dermal tissue matrix is rolled concentrically into a cylindrical structure.

6. The device of claim 1 , wherein the elongate element comprises a piece of acellular connective tissue.

7. The device of claim 6 , wherein the connective tissue is a tendon.

8. The device of claim 6 , wherein the connective tissue is a ligament.

9. The device of claim 1 , wherein the at least one sheet comprises multiple superimposed sheets.

10. The device of claim 1 , wherein the at least one sheet is divided into two halves when connected to the elongate element.

11. The device of claim 1 , wherein the at least one sheet is connected to the elongate element using surgical sutures.

12. The device of claim 1 , wherein the biomechanical strength of the at least one sheet is equal to that of the elongate element.

13. A method of closing a midline incision, comprising the steps of:

providing an implant comprising an elongate element having a first longitudinal axis and at least one sheet connected to the elongate element along the first longitudinal axis, wherein the at least one sheet comprises an acellular dermal tissue matrix derived from porcine dermis having a Young's modulus within a range of 49.5 MPa to 94.7 MPa;

positioning the elongate element along the midline incision; and

positioning the at least one sheet on at least one of an anterior side and a posterior side of a rectus abdominis muscle surrounding the midline incision.

14. The method of claim 13 , further comprising the step of creating spaces on the anterior or posterior sides of the rectus abdominis muscle for placement of the at least one sheet.

15. The method of claim 13 , further comprising the step of suturing the at least one sheet to the rectus abdominis muscle.

16. The method of claim 13 , wherein the at least one sheet is inserted between an anterior layer of fascia and the rectus abdominis muscle.

17. The method of claim 13 , wherein the at least one sheet is inserted between a posterior layer of fascia and the rectus abdominis muscle.

18. The method of claim 13 , wherein the at least one sheet is inserted over an anterior layer of fascia.

19. The method of claim 13 , wherein the at least one sheet is inserted below a posterior layer of fascia.

20. The method of claim 13 , wherein the acellular dermal tissue matrix is treated to remove antigens that are immunogenic to a human recipient.

21. The method of claim 13 , wherein the elongate element comprises a piece of acellular connective tissue.

22. The method of claim 21 , wherein the connective tissue comprises a tendon.

23. The method of claim 21 , wherein the connective tissue comprises a ligament.

24. The method of claim 13 , wherein the at least one sheet has a biomechanical strength that is equal to that of the elongate element.

25. The method of claim 13 , wherein the at least one sheet has a stretchability that is equal to that of the elongate element.

Assignments (8)